1 / 26

Adaptive immunity

Adaptive immunity. How can the immune system recognize so many different (previously unseen) insults? How does the immune system learn? How do B cells produce antibodies?. Antibody production after immunization. Irradiation prevents immune response.

oren-fitzgerald
Download Presentation

Adaptive immunity

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Adaptive immunity How can the immune system recognize so many different (previously unseen) insults? How does the immune system learn? How do B cells produce antibodies?

  2. Antibody production after immunization

  3. Irradiation prevents immune response

  4. Which cells can restore the immune response?

  5. Origins of lymphocytes

  6. B cells TC (Cytotoxic T cells) TH (Helper T cells) Also function in immune system

  7. Origins of lymphocytes

  8. Origins of lymphocytes

  9. Antibody protein structure

  10. B cell activation Each naïve B cell makes a single type of antibody with a unique binding specificity Upon activation the naïve B cell proliferates and produces progeny that secrete that antibody

  11. Antibody production after immunization

  12. Clonal selection

  13. Primary response Secondary response

  14. Antibody action:Activation of Complement Adaptive immunity (Innate immunity)

  15. Antibody action: Action of Complement

  16. Antibody action:IgG-mediated phagocytosis

  17. Antibody action:IgA is secreted

  18. Antibody action:IgE stimulates histamine production

  19. Antibody structure Determines antibody class

  20. Human heavy chain gene-segment pool IgM IgG IgD IgE IgA 51 x 27 x 6 = 8262 possible H chain variable regions 40 x 5 = 200 possible k light chain variable regions 116 possible l chain variable regions 2.6 million possible antigen binding sites from gene segment combinations

  21. Human heavy chain gene-segment pool 51 x 27 x 6 = 8262 possible H chain variable regions 40 x 5 = 200 possible k light chain variable regions 116 possible l chain variable regions 2.6 million possible antigen binding sites from gene segment combinations

  22. Human k light-chain gene rearrangement

  23. Ab gene usage in a pre-B cell (allelic exclusion)

  24. Clonal selection

  25. Memory cells: Somatic hypermutation in V regions Class switching

More Related