Investigation: Molecules to Man (and back)

1. Investigation: Molecules to Man (and back) Robert P. Kimberly, M.D. Howard Holly Professor of Medicine Senior Associate Dean for Research Director, UAB Arthritis and Musculoskeletal Center

2. Investigation: M2M and back • How to establish a career Identify a mentor, and have a coffee at least once a month Organize your lab, and don’t hesitate to use the HHMI website Understand the expectations for promotion Research productivity Teaching performance Service (resource, admin, clinical)

3. Investigation: Identify a mentor • Lucy's Coffee & Tea2007 University Blvd.328-2007In addition to coffee and tea, Lucy's offers sandwiches, salads, baked goods and more at good prices. Warm, friendly atmosphere, retro furniture and funky artwork. City Scene gave high marks to the smoked turkey sandwich, with smoked gouda, tomato chutney and arugula, served on toasted ciabatta bread from Edgar's Bakery.

4. Investigation: Organize your lab • HHMI “Making the Right Moves, A Practical Guide to Scientific Management for Postdocs and New Faculty” (http://www.hhmi.org/resources/labmanagement/index.html) • Staffing your lab • Mentoring • Getting funded • Project and data management • Setting up collaborations • Publications • Technology transfer

5. Investigation: Organize your lab • Occupational Health & Safety - radiation safety, chemical safety, etc. (http://www.healthsafe.uab.edu/) • Use of Animal Subjects – general information and species specific training (http://www.uab.edu/iacuc) • Use of Human Subjects – initial training and continuing education(http://www.uab.edu/irb) • Effort Reporting (http://main.uab.edu/show.asp?durki=79361)

6. Investigation: Organize your lab • Mandatory certifications • UAB Code of Conduct • (http://www.hrm.uab.edu/codeofconduct) • HIPAA • (http://www.hipaa.uab.edu/training.htm)

7. Investigations: Organize your lab

8. http://main.uab.edu/research • Administration and Oversight • Animal Resources Program (ARP) • Office of Research Compliance (Clinical Trials) • Conflict of Interest Review Board • UAB Fincial Affairs (Grants and Contracts Accounting) • Institutional Animal Care & Use Committee (IACUC) • Institutional Review Board (IRB) for Human Use • Occupational Health & Safety • Office of Grants and Contracts Administration (OGCA) • Office of Research Compliance • Office of Sponsored International Programs (OSIP) • Research Foundation (UABRF) • University Counsel Office

9. http://main.uab.edu/research • Facilities • Alabama Department of Public Health (ADPH) • Birmingham Regional Emergency Medical Services System (BREMSS) • Birmingham Veterans Affairs Medical Center (BVAMC) • Centers at UAB including those based in departments and schools • Jefferson County Department of Health (JCDH) • Center for Clinical and Translational Science (CCTS) Clinical Research Unit (CRU) • Southeast Biosafety Laboratory Alabama Birmingham (SEBLAB) • Southern Research • UAB Health System Facilities

10. http://main.uab.edu/research • Forms • Animal Resources Program(ARP) Forms • Conflict of Interest Review Board (CIRB) Forms • Financial Affairs (e.g., Accounting) Forms • Institutional Animal Care and Use Committee (IACUC) Forms • Institutional Review Board for Human Use (IRB) Forms • Occupational Health and Safety (OHS) Forms • Office of Grants and Contracts Administration (OGCA) Forms • UAB Research Foundation (UABRF) Forms

11. http://main.uab.edu/research • Graduate and Postdoctoral Training • International Research Training Programs • Office of Postdoctoral Education • The Graduate School • Technology Transfer and Economic Development • Innovation Depot - Office for the Advancement of Developing Industries (OADI) • UAB Research Foundation • UAB Research Park at Oxmoor

12. http://main.uab.edu/research • Regulatory Training BlazerNET (http://blazernet.uab.edu) – Blazer ID and PW to log in. • Research Tab- Check compliance courses taken • Effort Reporting • Diversity Training • HIPAA Training • IACUC Training • OH&S Training • IRB Training

13. http://medicine.uab.edu/research/ Faculty Development Resources UAB core facilities Budget and grant writing links Funding opportunities Compliance

14. Investigation: Expectations Research Productivity: How to choose an area for investigation Think broadly – the NIH Roadmap Look at UAB UWIRC Centers Look for translational opportunities

15. Investigation: Expectations • Government Resources (www.grants.gov) • Federal • State • Private Resources • Foundations and Associations • Nonprofit Centers • Charities • Internal Funding – University Sponsored Research Productivity: Funding

16. Investigation: Expectations • NIH resources for new investigators • http://grants.nih.gov/grants/new_investigators/resources.htm • Identify appropriate individual NIH career awards by using the wizard • http://grants.nih.gov/training/kwizard • All about grants - Tutorials • http://www.niaid.nih.gov/ncn/grants/default.htm • Annotated grant • Annotated summary statement

17. NIH Small Grant Program (R21) • New, exploratory and developmental research projects • Supports early stages of project development • May involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models or applications that could have major impact on a field of biomedical, behavioral, or clinical research • Should break new ground or extend previous discoveries toward new directions or applications

18. Associations & Foundations • American Heart Association • American Lung Association • American Cancer Society • Arthritis Foundation • Howard Hughes Medical Institute • National Marfan Foundation • Ellison Medical Foundation • Cystic Fibrosis Foundation • The Alzheimer’s Association • FRAXA Research American Heart Foundation • American Diabetes Foundation • Leukemia and Lymphoma Society. • Juvenile Diabetes Research Foundation • National Neurofibromatosis Foundation • Coulter Foundation

19. UAB Nominates Candidates: • Ellison Medical Foundation (Aging) • The John Merck Fund (Developmental Disabilities in Children) • The W. M. Keck Foundation's Distinguished Young Scholars in Medical Research • Pew Scholars Program • Burroughs Wellcome Biomedical Scholars • Howard Hughes • Daymon Runyon Foundation • Searle Scholars

20. Investigation: updates on funding • Join the UABRADM listserve • (http://www.uab.edu/uabra/uabradm_request.htm) • Join the Community of Science - keep your biosketch updated! • (www.cos.com) • Subscribe to the NIH NEXUS Listserve • (http://grants.nih.gov/grants/nexus.htm) • Search • (www.grants.gov) • Talk to your colleagues

21. The “Independent” Investigator • Publishes in high quality journals in a given area • Serves as a principal investigator of grants or contracts • Significant and sustained extramural funding • Supervises graduate students, post doctoral and clinical fellows • Initiates and participates in research collaborations

22. Investigation: M2M and back • How to establish a career Identify a mentor, and have a coffee at least once a month Organize your lab, and don’t hesitate to use the HHMI website Understand the expectations for promotion Research productivity Teaching performance Service (resource, admin, clinical)