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Proteins – part 1

Proteins – part 1. Proteins. Our third big biomolecule Review: the carbohydrate base unit is the _____________ the lipid base unit is the ________________ (for the hydrolyzable ones anyway!). Proteins. >50% of the dry weight of the body 100,000+ compounds Types of proteins: Catalytic

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Proteins – part 1

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  1. Proteins – part 1

  2. Proteins • Our third big biomolecule • Review: • the carbohydrate base unit is the _____________ • the lipid base unit is the ________________ (for the hydrolyzable ones anyway!)

  3. Proteins • >50% of the dry weight of the body • 100,000+ compounds • Types of proteins: • Catalytic • Transport • Regulatory • Structural • Contractile • Protective • Storage

  4. Protein unit: the amino acid • Amino acids • 20 required by mammals • 10 essential must be from diet • Four categories: • Nonpolar neutral • Polar neutral • Polar acidic • Polar basic • Natural amino acids are ____stereochemistry!

  5. Practice drawing: Glycine Valine Cysteine

  6. Amino acids in solution • Zwitterions • pI and pH

  7. Peptides: chains of amino acids • 1 amino acid + 1 amino acid = 1 dipeptide • 1 a.a. + 1 a.a. + 1 a.a. = 1 tripeptide • Oligopeptide • Polypeptide • Proteins

  8. Formation of the peptide bond dipeptide

  9. Peptide sequences • Name from N terminal to C terminal using three letter abbreviations • gly-cys-ala • Direction matters !! • gly-cys-ala is different from ala-cys-gly • Possible constitutional isomers for a given number of different amino acids = n!

  10. Amino acid exercise: • Three groups: draw out your share of the β-endorphin, met-enkephalin, and leu-enkephalin amino acid sequence • Draw from left to right, N-terminus to C-terminus, your amino acids on notecards using colored stickers • Link the notecards together, constructing correct peptide bonds. Overall charge at physiological pH:______

  11. Extra credit exercise (5 pts)

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