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Membranes in Biology

Dive into the intricate world of biological membranes with a focus on lipid bilayers, transmembrane proteins, protein motility, membrane deformation, and vesicle transport. Discover the complexity and dynamics of real-world membranes using quantitative tools and tomography techniques.

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Membranes in Biology

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  1. Rob Phillips California Institute of Technology Membranes in Biology (McMahon)

  2. Cells and Their Membranes

  3. Cells and Their Membranes

  4. Lipids

  5. Lipid Bilayers (In Vitro) Hydrophobic tails and polar head groups. Favorable for lipids to spontaneously assemble to form bilayers. (Avanti Polar Lipids) Molecular Continuum

  6. Membranes In Vivo Real biological membranes contain many different lipids & transmembrane proteins!

  7. The Complexity of Real-World Membranes

  8. The Motility of Proteins in Membranes

  9. Membrane Deformation in Biology (McMahon)

  10. Membrane Deformation in Biology (McMahon)

  11. Quantitative Tools for Tomography: Viral Budding as an Example HIV Budding Tomography producing wide range ofimagesof deformed membrane systems. (Dooher et al.) Observed Membrane Deformation During Cell Movement Calculated Deformation of Vesicle Due to Actin Polymerization (Medalia et al.)

  12. Vesicle Transport

  13. Vesicle Transport: Clathrin Coating

  14. Dynamin and Vesicle Fission (McMahon)

  15. Ion Channels and Transient Permeability Channels open in response to a variety of different stimuli. Key mechanisms are voltage gating, ligand binding-induced gating and mechanical tension in the membrane.

  16. Physics of Viral Budding (http://www.aids-info.ch/e_te/aas-e-imm.htm)

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