Occupational Hygiene and Sustainability

1. Occupational Hygiene andSustainability Steve Bailey GSK Sustainability & Environment

2. Pharma in the Millenium

3. Economic Recession U.S. unemployment was 9.7% in March 2010, the highest rate since 1983 and roughly twice the pre-crisis rate The Outstanding Public Debt as of 19 Mar 2010 is $12.6 trillion, and rising The National Debt has continued to increase an average of $4.05 billion per day since September 28, 2007 The estimated population of the United States is 308,038,602so each citizen's share of this debt is $41,116.79 “When we got into office, the thing that surprised me most was to find that things were just as bad as we’d been saying they were” John F. Kennedy

4. Social impacts “Trust in the world of business has evaporated as the world’s most severe economic crisis since the Great Depression is causing millions around the globe to lose their jobs and wiped out billions of dollars of invested capital.”  Charles H. Green, Trusted Advisor Associates 2009

5. Social impacts • SustainabilityRoad Map • Develop business strategies based on long- term trends • Innovate for sustainability and value • Think big - develop systemic answers • Refocus on partnerships with governments • Rebuild trust Business for Social Responsibility (2009)

6. Social impacts “The global economic and financial crisis as well as environmental concerns have brought sustainability into sharp relief.” PWC: Rebuilding the Global Economy (2009)

7. Business Impacts “We in big pharma should never take for granted our right to exist, our business model is not written into any country’s constitution. So we should be turning up for work every day with the mindset that we are earning the right to exist. We are earning it by meeting the expectations of society. When you start to think like this, you see the world differently.” Andrew Witty, CEO GlaxoSmithKline

8. “Sustainable development is development that meets the needs of the present without compromising the ability of future generations to meet their own needs.” Brundtland Commission, United Nations 1987

9. Humanity’s Ecological Footprint

10. Resource Depletion Pollution, Waste and Environmental Disturbances Goods and Services Natural Resources

11. The Triple Bottom Line Economic Sustainability means thinking about the future when we make decisions today It’s a way of life

12. Environmental Issues for Pharma

13. Access to medicines Patient safety Pricing of medicines etc Sustainability Challenges for Pharma • Innovation and pipeline • Generic vs. research • etc Growth and financialhealth Work Environmental footprint Community and workforce • Climate change • Water • etc

14. Pharmaceutical Products

15. What do our products do?

16. GSK’s Active Ingredients Approx. 2,400 Active Pharmaceutical Ingredients (APIs) and intermediates In-house exposure limits set from toxicology Classified by Occupational Hazard Categories (OHCs) 70% are OHC-3 or higher Skin exposure becomes an increasingly important route in the higher OHCs

17. Examples of OHCs Steroid Withdrawal Rash

18. Challenges of protection

19. Respirator-Free • A “Respirator-Free” environment is a workplace where: • containment at source rather than respirators (RPE) or protective clothing (PPE) is used as the primary form of control • airborne exposures are below the Occupational Exposure limit (OEL) • dermal exposure controlled • Our policy is that new and changed processes are designed to be Respirator-Free

20. Benefits of containment at source • Health - reduces risk of over-exposure and incidental exposure of co-workers • Quality - reduces risk of cross-contamination • Productivity - reduces cleaning, changing times, process interventions; improves ergonomics • Costs - reduces operating costs for respirator programme, breathing air supply, aircon and room ventilation • Employees - avoids discomfort and isolation; easier communications; improves safety • Environmental - reduces product losses, easier to treat releases

21. Energy savings & climate change Saving airflow at high performance fume hoods by better design and operation automatic sash closing saved 500 tonnes CO2 per year in one laboratory without affecting containment Recirculating filtered air instead of exhausting it using alarms to protect the employees 5% HVAC / AC 10% Process General utilities Lighting and office 10% 75%

22. Challenging the Standards 100fpm ?? 80fpm Face velocity 25cfm/ft2 10.7cfm/ft2 Flushing volume 6ft 4ft 6in Hood Width Operating cost savings 20%-50% with further improvements possible

23. From Occupational Hygiene …… to Sustainability • Licence to operate • Productivity • Operating costs • Product Quality Competitiveness Social Responsibility Environmental Responsibility • Health protection • Employee benefits • “Respect for People” • Environmental protection • Energy savings OH “Building Trust”

24. Pollution Prevention and Hygiene Types of Projects Input substitution 86% Preventive Maintenance 46% Water Conservation or Quality 31% In-process Recycling 23% Operations and Maintenance 20% 1989 Massachusetts Toxics Use Reduction Act:- changes in production processes or raw materials that reduce, avoid, or eliminate the use or generation of toxic or hazardous substances Roelofs et al. AOEH, 15(11), 843-850,2000

25. Chemicals Policy • Societal pressure to eliminate use of chemicals that harm the environment • Reflected in “Producer Responsibility“ regulations (eg. REACH) • Occupational hygiene benefits, eg. • substitution of Carcinogens, Mutagens and Reproductive toxins by the chemicals with the lowest toxicity and environmental impacts • designing processes that use benign conditions (eg. aqueous solutions rather than organic solvents)

26. Manufacture of APIs requires raw materials, reagents, solvents It involves many hazardous processes and wastes Introduction of sustainability principles is led by new products Encourages simplification and reduced use of materials Manufacture of APIs

27. Embedding sustainability into New Product Development

28. Source: Eco-Design Toolkit Methodology: Curzons AD, Constable DJC, Cunningham VL. 1999 Clean Products and Processes 1:82-90 and Jiménez-González C, Curzons AD, Constable DJC, Cunningham VL. 2005 J. of Clean Tech. and Env..Pol 7:42-50,

29. Chemical Legislation Guide

30. Conclusions

31. Sustainability @ GSK Environment, Health, Safety and Sustainability… a matter of policy Safeguard people and enhance their wellbeingProtect our communities and the environment Lead in what we do Make continuous improvement Integrate sustainability into our business Be transparent with everyone

32. Sustainability @ GSK Why… A sustainable business will build trust & • deliver more products of value • simplify the operating model • thrive in a culture of individual empowerment

33. GSK CEO Sustainability Awards • Environmental Sustainability • Health and Safety Sustainability • Sustainable Science and Technology

34. www.OHlearning.com

35. Help on Hand An animated demo is linked from the bottom of every page

36. A Successful Launch!

37. Sustainability @ GSK the power to build trust GSK Occupational Hygienists from around the world meeting in UK