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IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS

IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS. D. Bankovskiy(1, 2), G. Safonov(1) and Y. Kurilchuk(1). (1) Pokrov Plant of Biologics, Volginskiy, Russia. (2) All-Russian Research Institute of Veterinary Virology and Microbiology, Pokrov, Russia. Oral vaccination.

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IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS

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  1. IMMUNOGENICITY OF ERA G 333 STRAIN IN FOXES AND RACCOON DOGS D. Bankovskiy(1, 2), G. Safonov(1) and Y. Kurilchuk(1) (1) Pokrov Plant of Biologics, Volginskiy, Russia. (2) All-Russian Research Institute of Veterinary Virology and Microbiology, Pokrov, Russia.

  2. Oral vaccination • Two oral vaccines have been used for wild life rabies vaccination in Russia • Not enough vaccine quantity have been used for ORV campaigns • There was concern about safety and efficacy of vaccine rabies strains • Russia still needs a safe and efficient vaccine strain

  3. ERA G 333 • Created by reversed genetics • Have been received from collaborators at CDC • As part of BTEP program • Avirulent for 11 species of target and non target animals

  4. The immunogenicity experiment design. Part I: foxes

  5. The immunogenicity experiment design. Part II: raccoon dogs

  6. RESULTS 63% of foxes and 33% of raccoon dogs showed seroconversion by day 60 after vaccination. After challenge with virulent rabies virus strain 90% of foxes and 50% of raccoon dogs have survived.

  7. CONCLUSIONS • The appropriate immunogenicity of ERA G 333 for foxes and raccoon dogs has been shown in this experiment. • This strain is the strong candidate for new oral rabies vaccine. • The decision about future use of ERA G 333 strain can be made after the determination of immunity duration and minimal efficient doze of the vaccine virus.

  8. ACKNOWLEDGEMENTS • Pokrov Plant of Biologics • Staff of the Rabies Program of CDC • BTEP

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