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First Blueprint, Now Bricks: DNA is nanoscale construction material.

First Blueprint, Now Bricks: DNA is nanoscale construction material. Yamuna Krishnan The Chemical Biology Group National Centre for Biological Sciences, TIFR Bangalore 560 065, India yamuna@ncbs.res.in. TIFR. Adenine. Guanine. Thymine. Cytosine. 3.4 nm x 2. 2 nm.

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First Blueprint, Now Bricks: DNA is nanoscale construction material.

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  1. First Blueprint, Now Bricks: DNA is nanoscale construction material. Yamuna Krishnan The Chemical Biology Group National Centre for Biological Sciences, TIFR Bangalore 560 065, India yamuna@ncbs.res.in TIFR

  2. Adenine Guanine Thymine Cytosine 3.4 nm x 2 2 nm Structural DNA Nanotechnology Persistence length = 150 bp; 50 nm

  3. Reciprocal exchange

  4. Atomic Force Microscope imaging

  5. What can we build with this brick? Structures in 2D : Arrays Sequence of A,G,T & C = a string/seqence = DNA sequence is crucial. Each sequence must be unique = unique string. A unique sequence has a unique partner – exact complement Change of properties from single strand to duplex Mao, C. et al, J. Am. Chem. Soc.1999, 121, 5437

  6. 200X200 nm Liu et al, J. Am. Chem. Soc.2004, 126, 2324 1.2 mm Ding et al, J. Am. Chem. Soc.2004, 126, 10230 Triangular and Pseudohexagonal 2D arrays

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