510 likes | 528 Views
Explore heart transplant data, survival rates, risk factors, and patient outcomes over two decades from 1982 to 2001, including recipient demographics and post-transplant considerations.
E N D
HEART TRANSPLANTATION Overall
NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR * Number of Transplants * Numbers may be low due to delayed reporting.
AGE DISTRIBUTIONOF HEART RECIPIENTS(1982-2001) % of Transplants
1985-1996 1997-2001 AGE DISTRIBUTION OF HEART TRANSPLANT RECIPIENTS BY ERA
HEART TRANSPLANTATION Actuarial Survival(1982-2001) Half-life = 9.3 years Conditional Half-life = 11.8 years N=60,936
HEART TRANSPLANTATION Adult Recipients
ADULT HEART TRANSPLANTATIONActuarial Survival by Era (1982-2001) Survival (%) All comparisons significant at p < 0.002
ADULT HEART TRANSPLANTATION Actuarial Survival by Age Group(1982-2001) Survival (%) Survival comparisons All pair-wise comparisons are statistically significant at p < 0.05 except: 18-34 vs. 35-49 and 65-69 vs. 70+
271 124 170 32 32 31 29 64 88 35 95 22 ADULT HEART RE-TRANSPLANTS1-Year Survival
ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityIn Descending Order of Magnitude N=13,049
ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityIn Descending Order of Magnitude N=13,049
ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049
ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049
ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049
ADULT HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=13,049
ADULT HEART TRANSPLANTS (1996-2001)Factors Not Significant for 1 Year Mortality • Year of Transplant • In ICU or hospital prior to transplant • On inotropes for life support • ICD • CMV mismatch • Recipient pregnancy status • Weight (donor or recipient) • Height (donor) • Donor clinical infection • Donor cause of death
ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityIn Descending Order of Magnitude N=9,519
ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=9,519
ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=9,519
ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=9,519
ADULT HEART TRANSPLANTS(April 1994-December 1996)Factors Not Significant for 5 Year Mortality • Year of Transplant • VAD/ECMO/IABP • In ICU or hospital prior to transplant • On inotropes for life support • CMV mismatch • Recipient pregnancy status • Weight (donor or recipient) • Height (donor) • Donor clinical infection • Donor history of hypertension
ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearIn Descending Order of Magnitude N=7,738
ADULT HEART TRANSPLANTS(April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearContinuous Factors N=7,738
ADULT HEART TRANSPLANTS(April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearContinuous Factors N=7,738
ADULT HEART TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year:Combination of Donor Age and Center Volume
ADULT HEART TRANSPLANTS(April 1994-December 1996)Factors Not Significant for Conditional 5 Year Mortality
ADULT HEART RECIPIENTS Functional Status (April 1994-December 2001)
ADULT HEART RECIPIENTS Employment Status(U.S. Data: April 1994-December 2001)
ADULT HEART RECIPIENTSRehospitalization Post-transplant(April 1994 - December 2001)
ADULT HEART RECIPIENTSInduction Immunosuppression For follow-ups between October 1999 and December 2001
ADULT HEART RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between October 1999 and December 2001
ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001
ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 3,165) 5 Year Follow-up (N = 2,588)
ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001
POST-HEART TRANSPLANT MORBIDITY FOR ADULTSCumulative Incidence for Survivors (April 1994-December 2000)
Freedom from CAV and Freedom from Renal Dysfunction*For Adult Heart Recipients(April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant
MALIGNANCY POST-HEART TRANSPLANTATION FOR ADULTSCumulative Incidence for Survivors(April 1994-December 2001)
Freedom from MalignancyFor Adult Heart Recipients(April 1994-December 2000)
ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 3 Years(April 1994 - December 1998) N=6,851
ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 3 Years(April 1994 - December 1998)Continuous Factors N=6,851
ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 3 Years(April 1994 - December 1998)Continuous Factors N=6,851
ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 7 Years(April 1994 - December 1995) N=2,546
ADULT HEART TRANSPLANTATIONRisk Factors for CAV Within 7 Years(April 1994 - December 1995)Continuous Factors N=2,546
ADULT HEART TRANSPLANT RECIPIENTS: Cause of Death(1982-2001) Timing of Death
ADULT HEART TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 0-30 Days Year of Transplant
ADULT HEART TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 31 Days-1 Year Year of Transplant
ADULT HEART TRANSPLANTS RECIPIENTS:Cause of Death by Era: Deaths in >1 Year - 3 Years Year of Transplant
ADULT HEART TRANSPLANTS RECIPIENTS:Cause of Death by Era: Deaths in >3 Years - 5 Years Year of Transplant