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²É»ñ·ÇÏ é»³ÏódzݻñÇ ¹³ë³Ï³ñ·áõÙÁ (Coombs & Gell)

²É»ñ·ÇÏ é»³ÏódzݻñÇ ¹³ë³Ï³ñ·áõÙÁ (Coombs & Gell). I ïÇå ³Ý³ýÇɳÏïÇÏ (³ïáåÇÏ, 黳·ÇݳÛÇÝ) II ïÇå óÇïáïáùëÇÏ (óÇïáÉÇïÇÏ) III ïÇå ÇÙáõݳÏáÙåÉ»ùë³ÛÇÝ IV ïÇå µçç³ÛÇÝ ÙÇçÝáñ¹í³Í (¹³Ý¹³Õ»óí³Í ïÇåÇ). I ïÇå ³Ý³ýÇɳÏïÇÏ (³ïáåÇÏ, 黳·ÇݳÛÇÝ).

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²É»ñ·ÇÏ é»³ÏódzݻñÇ ¹³ë³Ï³ñ·áõÙÁ (Coombs & Gell)

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  1. ²É»ñ·ÇÏ é»³ÏódzݻñÇ ¹³ë³Ï³ñ·áõÙÁ (Coombs & Gell) I ïÇå ³Ý³ýÇɳÏïÇÏ (³ïáåÇÏ, 黳·ÇݳÛÇÝ) II ïÇå óÇïáïáùëÇÏ (óÇïáÉÇïÇÏ) III ïÇå ÇÙáõݳÏáÙåÉ»ùë³ÛÇÝ IV ïÇå µçç³ÛÇÝ ÙÇçÝáñ¹í³Í (¹³Ý¹³Õ»óí³Í ïÇåÇ)

  2. I ïÇå ³Ý³ýÇɳÏïÇÏ (³ïáåÇÏ, 黳·ÇݳÛÇÝ) • ØÇçÝáñ¹íáõÙ ¿ E, G4 Ig, áñáÝù ýÇùëíáõÙ »Ý å³ñ³ñï µçÇçÝ»ñÇ ¨ µ³½áýÇÉÝ»ñÇ íñ³ • öáõÉ»ñÁª • ê»ÝëǵÇÉǽ³ódz • ä³ÃáùÇÙÇ³Ï³Ý • ä³ÃáýǽÇáÉá·Ç³Ï³Ý

  3. I ïÇå. ë»ÝëǵÇÉǽ³ódz • µÝ³ÏãáõÃÛ³Ý Ùáï 50%-Ç Ùáï Ç å³ï³ëË³Ý û¹áõÙ ³éϳ ³É»ñ·»ÝÝ»ñÇ ëÇÝû½íáõÙ »Ý IgE, µ³Ûó ÙdzÛÝ 10% Ùáï »Ý ½³ñ·³ÝáõÙ ÏÉÇÝÇÏ³Ï³Ý Ýß³ÝÝ»ñ • IgE ³é³ç³óáõÙÁ T ÉÇÙýáóÇï ϳËÛ³É ¿. ÃÇÙáõëÇ Ñ»é³óáõÙÁ ϳÝËáõÙ ¿ ¹ñ³Ýó ëÇÝû½Á • ÆÈ4, áñÝ ³é³ç³óÝáõÙ »Ý CD4+ TH2 ÉÇÙýáóÇïÝ»ñÁ Ýå³ëïáõÙ ¿ IgE ëÇÝû½ÇÝ

  4. I ïÇå. ë»ÝëǵÇÉǽ³ódz Ig G/M Ig E IL4/TNF÷áËѳñ³µ»ñáõÃÛáõÝÁ áñáßÇã ¿ Ig E ëÇÝû½Ç ѳٳñ

  5. ä³ñ³ñï µçÇç

  6. ´áñµáùáõÙ ²É»ñ·»ÝÝ»ñ ÞÝãáõÕÇÝ»ñÇ ·»ñ½·³ÛáõÝáõÃÛáõÝ ÊóÝÇãÝ»ñª ùñáÝÇÏ ÑÇí³Ý¹áõÃÛáõÝÝ»ñ, óáõñï, ýǽÇÏ³Ï³Ý µ»éÝí³ÍáõÃÛáõÝ ú¹Ç ÑáëùÇ Ë³Ý·³ñáõÙÝ»ñ

  7. ´ñáÝËÇ³É ³ëÃÙ³Ûáí ÑÇí³Ý¹Ç ÃáùÁ ÉáñÓ³ÛÇÝ Ëó³ÝáõÙÝ»ñáí

  8. ²É»ñ·»ÝÇ ¹»ñáõ٠ѳݹ»ë »Ý ·³ÉÇë µçÇçÝ»ñÇ Ã³Õ³ÝÃÝ»ñÇ ýÇùëí³Í ùÇÙÇ³Ï³Ý ÝÛáõûñ, ¹»Õ³ÝÛáõûñ Ù³Ïñáý³· T ÉÇýáóÇï B ÉÇýáóÇï Ig G1,2,3, M ²ÝïÇ·»ÝÇ ÏñÏݳÏÇ ³½¹»óáõÃÛáõÝ ÂÇñ³Ë µçÇçÝ»ñÇ Ù³Ï»ñ»ëÇÝ ³ÝïÇ·»Ý-ѳϳٳñÙÇÝ ÏáÙåÉ»ùëÝ»ñÇ ³é³ç³óáõÙ ÏáÙåɻٻÝïÇ ³ÏïÇí³óáõ٠гϳٳñÙÇÝÝ»ñÇÇ Fc ýñ³·Ù»ÝïÇ ÏáÝï³Ïï ÏÇÉ»ñÝ»ñÇ é»ó»åïáñÝ»ñÇ Ñ»ï C3b -> ûåëáÝǽ³ódz C3b56789 óճÝà ·ñáÑáÕ ÏáÙÉ»ùëÇ ·áÛ³óáõÙ ÑÛáõëí³ÍùÝ»ñÇ íݳëáõÙÝ»ñ, ÇÙáõÝ µáñµáùáõÙ

  9. III ïÇå • ·ÉáÙ»ñáõÉáÝ»ýñÇï • ßÇ×áõϳÛÇÝ ÑÇí³Ý¹áõÃÛáõÝ • í³ëÏáõÉÇïÝ»ñ Ig A, G, M C Ñ-ñ·

  10. IV ïÇå (T ÙÇçÝáñ¹í³Í) • CD4+ (Ñ»Éå»ñ) T ÉÇÙýáóÇïÝ»ñ -¦ (ûñ. ·ñ³Ýáõɻٳïá½ ÑÇí-Ý, ÏáÝï³Ïï³ÛÇÝ ¹»ñÙ³ïÇï) • CD8+ (óÇïáïáùëÇÏ) T ÉÇÙýáóÇïÝ»ñ-¦ (ûñ.íÇñáõëÝ»ñáí µ»éÝí³Í µçÇçÝ»ñÇ ÉǽÇë)

  11. ÎáÝï³Ïï³ÛÇÝ ¹»ñÙ³ïÇï

  12. Îáñ»ÏódzÛÇ áõÕÇÝ»ñÁ (I ïÇåÇ ûñÇݳÏáí) ä³ñ³ñï µçÇçÝ»ñÇ ¹»·ñ³ÝáõÉÛ³ódz ²Ý³ýÇɳùëdzÛÇ ÙÇçÝáñ¹Ý»ñ î»Õ³ÛÇÝ ³Ý³ýÇɳùëdz Ig E ëÇÝû½ ³É»ñ·»Ý гϳ-ÑÇëï³ÙÇݳÛÇÝ ÙÇçáóÝ»ñ ä³ñ³ñï µçÇçÝ»ñÇ ëï³µÇÉǽ³ïáñÝ»ñ, ǽáåñ»Ý³ÉÇÝ ³É»ñ·»ÝÇ Ñ»ï ÏáÝï³ÏïÇó Ëáõë³÷áõÙ ÐÇåáë»Ý-ëǵÇÉǽ³ódz àõß ÷áõÉÇ ÇÝÑǵÇïáñÙ»ñ, ëï»ñáǹݻñ

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