1 / 7

Hematopathology, Case 4

Explore a case of a 60-year-old male with splenomegaly and abnormal blood counts indicative of Chronic Myelogenous Leukemia. Learn about peripheral blood smear findings, differential diagnosis, and bone marrow biopsy results.

bittler
Download Presentation

Hematopathology, Case 4

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Hematopathology, Case 4 • A 60 year-old male presents with mild fatigue. Physical examination is remarkable for splenomegaly to the level of the umbilicus. CBC WBC 75.1x103/mL Hemoglobin 8.5g/dL Hematocrit 25.5% Platelets 56,000/mL MCV 88.4 femtoliters (fL) RDW 16.1

  2. band myelocyte Promyelocyte (late stage) C B A Describe the findings on the peripheral blood smear

  3. band myelocyte Promyelocyte (late stage) -WBCs are markedly WBCs are markedly increased in number, predominantly cells of the neutrophil series. -Many mature neutrophils are seen as well as earlier forms (A, B, C)

  4. Many of the above white blood cells were also present on the peripheral smear. Identify the cell.

  5. Basophil The basophilic granulocyte is characterized by large, coarse, aggregated dark purple granules. The nuclear lobes are usually not very well visible and masked by the granules

  6. Differential Diagnosis? • While leukocytosis and neutrophilia can be reactive, for example to an infection, the markedly elevated WBC count (>30) and basophilia are not characteristic of an inflammatory process • A bone marrow biopsy was done. The bone marrow was hypercellular with myeloid and megakaryocytic hyperplasia and erythroid hypoplasia

  7. Diagnosis? • Chronic Myelogenous Leukemia (CML)

More Related