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Hematopathology, Case 7

Hematopathology, Case 7. A 51 year-old male presents with fatigue, malaise and occasional low grade fevers. Physical examination reveals bilateral non-tender cervical lymphadenopathy and an enlarged inguinal lymph node. CBC WBC 6.2x103/mL, Hemoglobin 11.8g/dL Hematocrit 36.1%

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Hematopathology, Case 7

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  1. Hematopathology, Case 7 A 51 year-old male presents with fatigue, malaise and occasional low grade fevers. Physical examination reveals bilateral non-tender cervical lymphadenopathy and an enlarged inguinal lymph node. CBC WBC 6.2x103/mL, Hemoglobin 11.8g/dL Hematocrit 36.1% MCV 92.0 femtoliters (fL) RDW 16.1 Platelets 180,000/mL

  2. Describe the low power microscopic findings

  3. In contrast to the reactive node, follicles are distributed throughout the nodal • parenchyma. The follicles appear to be “back-to-back”

  4. Describe the high power microscopic findings

  5. At higher magnification, follicles are composed predominantly of small lymphocytes. Instead of round nuclei, these lymphocytes have angular, irregular or cleaved nuclear contours (“small cleaved lymphocytes”) Diagnosis? Follicular Lymphoma

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