Supplemental Figure 3

1. Supplemental Figure 3 Time course of mean arterial pressure, albuminuria, and kidney injury after reduction in renal mass and treatment of C57BL/6 mice with deoxycorticosterone acetate + saline drinking water (DOCA) or treatment of CD-1 mice with hydralazine C57BL/6 mice treated with DOCA-salt (with saline drinking water) after 5/6 Nx (5/6 Nx) or sham surgery (sham) had higher MAP than controls with saline drinking water only (NSS oral) (A, B, left panel); however DOCA-salt resulted in modest albuminuria (C, left panel) and did not increase kidney injury, as measured by serum creatinine (D, left panel). CD-1 mice treated with hydralazine (Hyd) in drinking water after 5/6 Nx (5/6 Nx) or sham surgery (sham) had lower MAP than controls with drinking water only (A, B, right panel); however hydralazine had modest decreases in albuminuria (C, right panel) and did not decrease kidney injury, as measured by serum creatinine (D, right panel). †, P<0.005 vs baseline in each group; ††, P<0.05 vs baseline in each group; *, P<0.005 5/6 Nx with drug administration vs 5/6 Nx control; **, P<0.05 5/6 Nx with drug administration vs 5/6 Nx control; #, P<0.005 sham with drug administration vs sham control; ##, P<0.05 sham with drug administration vs sham control.