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Regularitati ascunse si corelatii in nano-bio-structuri

Regularitati ascunse si corelatii in nano-bio-structuri. M. Popescu, A. Velea. Workshop Exploratoriu: "Nano Sisteme Dinamice: de la Concepte la Aplicatii Senzoristice"  22-23 septembrie 2010, Bucuresti. Cuprins. Introducere Metode Colagen α 1(I) uman Interferon β Concluzii.

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Regularitati ascunse si corelatii in nano-bio-structuri

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  1. Regularitati ascunse si corelatii in nano-bio-structuri M. Popescu, A. Velea Workshop Exploratoriu: "Nano Sisteme Dinamice: de la Concepte la Aplicatii Senzoristice" 22-23 septembrie 2010, Bucuresti

  2. Cuprins • Introducere • Metode • Colagen α1(I) uman • Interferon β • Concluzii

  3. Introducere

  4. Metode • Pair correlation • Se calculeaza numarul de perechi de aminoacizi de acelasi fel situati la anumite distante unul de celalalt • Se determina functia de corelare de perechi • Fast Fourier Transform

  5. Colagen α1(I) uman MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPTGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKDKRHVWFGESMTDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGFDVGPVCFL 1464 aminoacizi

  6. Colagen α1(I) uman Pozitionari in lant:

  7. Colagen α1(I) uman FFT:

  8. Colagen α1(I) uman Distante intre aminoacizi de acelasi tip:

  9. Colagen α1(I) uman Probabilitati de legare intre doi aminoacizi X si Y in lantul de colagen α1(I) uman: LegXY= nr de legaturi X-Y LegYX= nr de legaturi Y-X NrX= numarul de aminoacizi X din lantul colagenului NrY= numarul de aminoacizi Y din lantul colagenului

  10. Interferon β 187 aminoacizi MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

  11. Interferon β Pozitionari in lant:

  12. Interferon β FFT:

  13. Concluzii • Aplicarea metodelor statistice in moleculele cu lanturi mari permite obtinerea de argumente pentru ordonarea partiala a aminoacizilor si obtinerea de corelatii intre aminoacizi. • Atunci cand aminoacizii sunt folositi pentru construirea unor lanturi lungi si complicate metodele statistice sunt eficiente pentru dezvaluirea structurii primare a biomoleculelor.

  14. Va multumesc pentru atentie!

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