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Magnesium, Menstrual Migraines, & PMS

Magnesium, Menstrual Migraines, & PMS. By: Tori Couch. What is PMS?. Premenstrual Syndrome (PMS) is characterized by emotional, behavioral, and physical symptoms that occur during the luteal phase before the menstrual period. All symptoms vary in severity 20-80% PMDD.

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Magnesium, Menstrual Migraines, & PMS

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  1. Magnesium, Menstrual Migraines, & PMS By: Tori Couch

  2. What is PMS? Premenstrual Syndrome (PMS) is characterized by emotional, behavioral, and physical symptoms that occur during the luteal phase before the menstrual period. All symptoms vary in severity 20-80% PMDD

  3. What are Menstrual Migraines? International Headache Society Migraine without aura that occur during 5-day premenstrual period 2 days before to 3 days after onset of menstruation 2 out of 3 cycles Affects 11-14% of the population

  4. Magnesium • Important for nerve transmission • Heart & Muscle contraction • Insulin release from the pancreas • Dilates arteries • Aids in enzyme function

  5. Magnesium2+ • Regulates neurotransmitters & 325 enzyme systems • Low Mg2+: • Produce cerebrovascular constriction • Increased vascular reactivity • Membrane receptor activity to mediators (serotonin)

  6. Modified-Release Magnesium 250mg Tablet Quaranta S., et al. (2007). Pilot Study of the Efficacy and Safety of Modified-Released Magnesium 250mg Tablet for the Treatment of Prementrual Syndrom. Clin Drug Invest; 27(1); 51-58. Women aged 18-45 years with regular menstrual cycles, affected by PMS >25 pts on MMDQ Italy 2004-2006 3-month observation period followed by a 3-month treatment period 1-screening visit 2-control visit After 3 menstrual cycles occurred on treatment

  7. Classification of PMS Symptoms Quaranta S., et al. (2007). Pilot Study of the Efficacy and Safety of Modified-Released Magnesium 250mg Tablet for the Treatment of Prementrual Syndrom. Clin Drug Invest; 27(1); 51-58.

  8. Results 38 patients Caucasian except 2 Screening 1 – visit & visit 2 – control visit Screen 3 – end of 3 month treatment phase. MMDQ Diary

  9. PMS Symptom Scores during Treatment

  10. Conclusion Study #1 • Modified-release magnesium tablet • Magnesium ions coincident with circadian rhythms of hormones related to PMS symptoms • 2am melatonin, 10pm-2am LH • Peaks of estradiol and prolactin

  11. Serum Ionized Magnesium Levels & Menstrual Migraines Mauskop, A., et al. (2002). Serum Ionized Magnesium Levels and Serum Ionized Calcium/Ionized Magnesium Ratios in Women with Menstrual Migraine. Headache. 42:242-248. • 61 women with migraine without aura during menstruation at The International Headache Society (IHS) • = occurred within a week of onset menstruation. • IMg2+, ICa2+ and TMg levels measured, & ICa2+/Img2+ ratios calculated

  12. Mauskop, A., et al. (2002). Serum Ionized Magnesium Levels and Serum Ionized Calcium/Ionized Magnesium Ratios in Women with Menstrual Migraine. Headache. 42:242-248.

  13. Conclusion of Study Low Mg2+ (extracellular/intracellular) known to produce cerebrovascular constriction and increased vascular reactivity and membrane receptor activity (mediated by influx & release of Ca2+) High incidence of Mg2+ deficiency in patients during menstrual migraine attacks indicate that Mg may have a role in the development of this disease. Significant difference in IMg2+ between women with low to normal serum IMg2+ levels suggest that this abnormality plays a key role only in certain group of women and not continuously distributed.

  14. Conclusion Continued Recent evidence indicates that in young, healthy cycling women and on isolated, primary cerebrovascular muscle cells in culture, circulating levels of estrogen and progesterone play major roles in regulating levels of circulatory Mg2+ and Ca2+. It could be said that in women with low serum IMg2+, hormonal actions on Mg2+ may be responsible for the menstrual migraine syndrome and administration of Mg2+ to those women may be effective in terminating headache attacks.

  15. Resources MacGregor, A. (2010). Prevention and Treatment of Menstrual Migraine. Drugs, 70(14), 1799-1818. Retrieved from Ebscohost: Medline. Mauskop, A., Alutra, B. T., Altura, B. M. (2002). Serum Ionized Magnesium Levels and Serum Ionized Calcium/Ionized Magnesium Ratios in Women with Menstrual Migraine. Headache, 42, 242-248. Retrieved from Ebscohost: Medline. Quaranta, S., Buscaglia, M. A., Meroni, M. G., Columbo, E., Cella, S. (2007). Pilot Study of the Efficacy and Safety of a Modified-Release Magnesium 250mg Tablet (Sincromag ®) for the Treatment of Premenstrual Syndrome. Clin Drug Invest, 27(1), 51-51. Retrieved from Ebscohost: Medline.

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