1 / 8

Creating a Cell Cycle/Cancer Problem Space

Creating a Cell Cycle/Cancer Problem Space. Janet Cooper Lisa Felzien Laura Salem. Creating a Cell Cycle/Cancer Problem Space: the essential components. Our Goal: To create a problem space using the principles of the cell cycle and its implications on cancer research.

bruce-weiss
Download Presentation

Creating a Cell Cycle/Cancer Problem Space

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Creating a Cell Cycle/Cancer Problem Space Janet Cooper Lisa Felzien Laura Salem

  2. Creating a Cell Cycle/Cancer Problem Space: the essential components

  3. Our Goal: To create a problem space using the principles of the cell cycle and its implications on cancer research. This problem space will be adapted to use in non-majors biology, general biology, genetics, and cell biology.

  4. Biological Principles • -cell cycle • -cancer • -protein motifs/domains • -sequence alignment • -protein structure • -cyclins/CDKs • Analysis Tools • -Saccharomyces Genome Database • -NCBI/Entrez • -Workbench • Data Sets • -nucleotide sequences of cancer genes • -protein sequences of cancer genes

  5. Using Saccharomyces cerevisiaeas a model for studying the cell cycle

  6. A Subset of Cell Cycle Genes in Yeast with Human Cancer Homologs CDC25 CDC28 CDC27 CDC34 http://www.yeastgenome.org/ http://cc.ucsf.edu/people/waldman/GENES/completechroms.html

  7. Data sets • Sequences generated from genbank and BLAST • Nucleotide alignment comparison with students in workbench • Question posing by students • Use of workbench tools

  8. Student questions and goals • Questions: • Are there common regions for mutations? • How do the mutations affect the function of the protein? • Objectives for Genetics/Cell Biology: • Analysis of the effects of mutations • Determination of nucleotide sequence and protein structure relationships • Familiarity with computational tools

More Related