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The development and impact of animal cloning. What is cloning ?. -Natural Cloning. Cloning is the process of creating an identical copy of an original. -Artificial Cloning. *Reproductive cloning. *Therapeutic cloning. Reproductive cloning. -Technique
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What is cloning ? -Natural Cloning Cloning is the process of creating an identical copy of an original. -Artificial Cloning *Reproductive cloning *Therapeutic cloning
Reproductive cloning -Technique -Somatic Cell Nucleus Transfer (SCNT) -procedure of creating exact copy of an original. Procedure -mentioned in Biology notes
Development 1938 Hans Spemann proposed an experiment to transfer one cell's nucleus into an egg without a nucleus (SCNT) 1928 Hans Spemann performs first nuclear transfer experiment. 1952 Tadpole ,cloned by Briggs and King. 1962 Frogs ,cloned by John Gurdon 1963 Carp
1978 A worldwide debate on cloning ethics 1986 Steen Willadsen cloned cattle 1997 Sheep (Dolly) ,Mice 1998 Lamb (Polly) 1977 Mice ,cloned by Karl Illmensee 2000 Monkey (Tetra), pigs , Asian guar 2001 Cat ,OX , Cattle
2003 Mule ,Rabbit ,Horse ,Rat 2004 Fruit Flies, Human embryo 2002 Scientists try to clone Thylacine (Tasmanian Tiger) 2005 Dog 2005 Project was stopped Recently , the project has been revived
Impact of reproductive cloning • Cloning animals especially extinct species -Cloning pets Positive : • Infertility • Cloning Human Beings
Discussion Should human beings be cloned ?
-strange anomalies -commercialization and industrialization -unethical experimentation Negative impact : -population -right
Therapeutic cloning Technique -Somatic Cell Nucleus Transfer (SCNT) -procedure for creating stem cells genetically compatible with the patient. Procedure • Developed into blastocyst • Stem cells obtained
Development - The first successful therapeutic cloning was accomplished in 2001- November - Started in 2000 - legal for research purposes in the United Kingdom - In many other countries, the practice is banned
Impact -Research • Reverse heart attacks • Produce organs or tissues Positive impact • Cure diseases e.g Alzheimer's disease, Parkinson's disease, diabetes
Example Cause • Loss of Dopamine Parkinson's disease -movement disorder Treatment - Inject Levodopa (L-DOPA )
Discussion Should stem cells in cloned embryo be extracted to cure disease ?
Impact Moral and ethical issues • Immoral to create an embryo solely for research • Harvesting the stem cells kill embryos Negative impact -Origin of ova - Method of obtaining eggs - Mutated stem cells