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RESPIRATORY SYSTEM EMBRYOLOGY. Dr Shivaram Bhat. Parts of Respiratory tract. Upper RT – nose, nasal cavity, pharynx Lower RT – larynx, trachea, bronchi, lungs. LEARNING OBJECTIVES. Formation of laryngotracheal diverticulum Devlopment of larynx Development of lungs
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RESPIRATORY SYSTEMEMBRYOLOGY Dr ShivaramBhat
Parts of Respiratory tract • Upper RT – nose, nasal cavity, pharynx • Lower RT – larynx, trachea, bronchi, lungs
LEARNING OBJECTIVES • Formation of laryngotrachealdiverticulum • Devlopment of larynx • Development of lungs • Anomalies of trachea and lungs
Questions • Embryology of lungs • Laryngotrachealdiverticulum • Tracheooesophageal fistula • Stages of maturation of lungs
Time line • 4 weeks – laryngotrachealdiverticulum • 5-16 week – terminal brochiole (PG stage) • 16-26 week – resp. bronchiole, alv. Duct (canalicular stage) • 26 week-birth – prim. alv. (saccular stage) • 8 months – 8 yrs – true alv. (alv. stage)
Anomalies • Laryngeal atresia/stenosis • Laryngeal web
Anomalies • Tracheo-esophageal fistula • VACTERL association • Tracheal bronchus • Agenesis, hypoplasia • Abnormal lobes • Azygos lobe, accessory lobe • Congenital polycystic lung (honey comb lung)
Clinical /forensic significance • Foetal lung vs adult lung • Hyaline membrane disease/ respiratory distress syndrome