1 / 20

Amines & Amides

Amines & Amides. Dr. Michael P. Gillespie. Introduction. Amines and Amides contain nitrogen. Nitrogen is an important component in the structure of the nucleic acids DNA and RNA. Amines are characterized by the presence of an amino group (-NH 2 ).

candid
Download Presentation

Amines & Amides

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Amines & Amides Dr. Michael P. Gillespie

  2. Introduction • Amines and Amides contain nitrogen. • Nitrogen is an important component in the structure of the nucleic acids DNA and RNA. • Amines are characterized by the presence of an amino group (-NH2). • Histamine contributes to the inflammatory response. Dr. Michael P. Gillespie

  3. Introduction • Amides are the products of a reaction between an amine and a carboxylic acid derivative. • Amino acids are the subunits from which proteins are built. They are characterized by both an amino group and a carboxyl group. Dr. Michael P. Gillespie

  4. Amines: Structure & Properties • Amines are a family of compounds that are contain an amino group or substituted amino group. Dr. Michael P. Gillespie

  5. Amines Dr. Michael P. Gillespie

  6. Medically Important Amines • Amphetamines, such as benzedrine and methedrine, stimulate the central nervous system. They elevate blood pressure and pulse rate and are often used to treat fatigue. • Medically, they have been used to treat depression and epilepsy. • Amphetamines decrease the appetite and have been prescribed as diet pills. Dr. Michael P. Gillespie

  7. Medically Important Amines • Many of the medical amines are analgesics (pain relievers) or anesthetics (pain blockers). • Novacaine is used as a local anesthetic. • Demerol is a very strong pain reliever. • Ephedrine is used as a decongestant. • Sulfa drugs used to fight bacterial infections are made from amines. Dr. Michael P. Gillespie

  8. Methamphetamine • Methamphetamine is an addictive drug known by many names such as “speed”, “crystal”, “crank”, “ice”, and “glass”. • Ephedrine, which is used as a nasal decongestant, can be used as the starting material for methamphetamine. • Methamphetamine can be smoked, taken orally, snorted, or injected depending upon the form of the drug. • It stimulates the release of dopamine and norepinephrine into regions of the brain that control feelings of pleasure. Dr. Michael P. Gillespie

  9. Methamphetamine • Symptoms of long-term abuse include addiction, anxiety, violent behavior, confusion, psychotic symptoms of paranoia, hallucinations, and delusions. • In severe cases paranoia results in homicidal and / or suicidal feelings. • Elevated heart rate and blood pressure can lead to strokes. • In severe cases, cardiovascular collapse and death result. Dr. Michael P. Gillespie

  10. Heterocyclic Amines • Heterocyclic amines are cyclic compounds that have at least one nitrogen atom in the ring structure. Dr. Michael P. Gillespie

  11. Amides: Structure & Properties • Amides are formed in a reaction between a carboxylic acid derivative and an amine. • The amine bond is the bond between the carbonyl carbon of the acyl group and the nitrogen of the amine. Dr. Michael P. Gillespie

  12. Amides Dr. Michael P. Gillespie

  13. Medically Important Amides • Barbiturates (“downers”) are derived from amides and are used as sedatives. • Acetaminophen is an amide. Dr. Michael P. Gillespie

  14. Neurotransmitters • Neurotransmitters are chemicals that carry signals from a nerve cell to a target cell. • The signals can be inhibitory or excitatory and they are all nitrogen containing compounds. Dr. Michael P. Gillespie

  15. Catecholamines • The catecholamines include dopamine, norepinephrine, and epinephrine. • Too little dopamine produces Parkinson’s disease. • Too much dopamine is associated with schizophrenia. Dr. Michael P. Gillespie

  16. Serotonin • A deficiency of serotonin is associated with depression and eating disorders. • Serotonin is also involved in pain perception, regulation of body temperature, and sleep. Dr. Michael P. Gillespie

  17. Histamine • Histamine contributes to allergy symptoms. Dr. Michael P. Gillespie

  18. γ-Aminobutyric Acid & Glycine • γ-Aminobutyric Acid (GABA) & Glycine are inhibitory neurotransmitters. • It is believed that GABA is involved in control of aggressive behaviors. Dr. Michael P. Gillespie

  19. Acetylcholine • Acetylcholine is a neurotransmitter that functions at the neuromuscular junction. • It carries signals from the nerve to the muscle. Dr. Michael P. Gillespie

  20. Nitric Oxide & Glutamate • Nitric oxide and glutamate function in a positive feedback loop. • They are thought o be involved in learning and the formation of memories. Dr. Michael P. Gillespie

More Related