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Amides

Amides. By Johanna Entz and Vicky Baba. Overview. General Amide Information Structure of an Amide Naming Amides Synthesis of Amides from Acid Chlorides Amide Uses. General Information. Amides are the result from the replacement of the OH in –COOH with and –NH2

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Amides

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  1. Amides By Johanna Entz and Vicky Baba

  2. Overview • General Amide Information • Structure of an Amide • Naming Amides • Synthesis of Amides from Acid Chlorides • Amide Uses

  3. General Information

  4. Amides are the result from the replacement of the OH in –COOH with and –NH2 • Amides are polar and are soluble (they can mix with water) • Except for menthanamide • Most amides are solids at room temperature (melting points are high because amides can form hydrogen bonds) www.f.u-tokyo.ac.jp/~yakka/Figure-E1r.gif

  5. Structures of Amides

  6. Steps for making an amide structure • Molecule+COOH (carboxylic acid) • Remove the –OH • Move one bond to O, making a double bond attachment to the O • Add NH2 • Amides have a Planar structure

  7. Naming Amides

  8. Steps for Naming Amides When dealing with a molecule: • Take name of parent chain • Remove the ending –e • Replace with –amide When dealing with an acid: • Take name acid • Remove the –oic ending • Replace with -amide

  9. Example 1

  10. Example 2

  11. Example 3

  12. Synthesis of Amides from Acid Chlorides

  13. Amides are formed when ethanoyl chloride and ammonia react and a double replacement reaction occurs, producing ethanamide and solid ammonium chloride • This reaction involves a violent reaction, producing white smoke and heat along with a mixture of ethanamide and ammonium chloride Watch from the 3:08 minutes http://www.youtube.com/watch?v=G-k08VVz0Vc

  14. Amide Uses

  15. LSD • Amides have a wide variety of uses from peptides, which are used to break down proteins in your stomache, to LSD or lysergic acid diethylamide, the muse for The Beatles “Lucy in the Sky with Diamonds” and literary works such as Alice in Wonderland. • Other used for amides include: • Acetominophen, a pain reliever • Caffeine • Deet, or bugspray www.lycaeum.org/diseyes/olo/lsd.gif

  16. Acetominophen www.theodora.com/drugs/images/1347.jpg

  17. Caffeine www.3dchem.com/imagesofmolecules

  18. N-dimethyl-m-toluamide (DEET) www.3dchem.com/imagesofmolecules/deet.jpg

  19. References Amides.cgcc.17Sept.2009. < www.cgcc.cc.or.us/…/Notes%20Amino%20and%Amides.doc > Amide Synthesis.Youtube.17Sept.2009.ChemCorner.27Jan.2009.< http:/www.youtube.com/watch?v=G-k08VVz0Vc > Bruner, Bob.Amides.bbruner.17Sept.2009.Bob Bruner.12Aug.2009.< http://bruner.org/obc/amide.htm > Clark, Jim. Introducing Amides. Chemguide.17Sept.2009. Jim Clark 2004. 2004. <http://www.chemguide.co.uk/organicgroups/amides/background.html#top > Hornback, Joseph M. Organic Chemistry:University of Denver. Toronto.Brooks/Cole Publishing Company.1998

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