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1. Public Health East Cumbria VTS March 2010
3. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
4. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
5. Public Health Griffiths S, Jewell T, Donnelly P. Public Health;119(10):907-913 Oct 05. Public Health in Practice: the Three Domains of Public Health.
Health Improvement
Improving Services
Health Protection
6. Health Improvement Inequalities
Education
Housing
Employment
Family/community
Lifestyles
Surveillance and monitoring of specific diseases and risk factors
7. Improving Services Clinical effectiveness
Efficiency
Service planning
Audit and evaluation
Clinical governance
Equity
8. Health Protection Infectious diseases
Chemicals and poisons
Radiation
Emergency response
Environmental health hazards
9. NHS in Cumbria
10. NHS in Cumbria
11. Health Protection Agency
12. Health Protection Agency
13. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
14. Routine Immunisations
15. Non Routine Immunisations
16. MMR Vaccine
17. BCG Vaccine 60% efficacy
Lasts 10-12 years
Boosters ineffective
Side effects
Universal BCG at 13 years
NNT to prevent one (treatable) case = 20,000
18. TB Control: Targeted Approach Most cases originate in high risk countries
Port health
BCG in infancy in high incidence communities
Non infectious after 2 weeks treatment
Effective treatment and contact tracing
Some occupational groups still get BCG
Healthcare workers
Travel health
19. HPV Immunisation Programme
20. HPV Immunisation Programme Cervical Cancer
2nd most common female cancer in UK
England: 2,200 cases and 800 deaths / yr
Human Papilloma Virus
80% Sexually-active women infected at some time
Mostly clears spontaneously in 6-12 months
Mucosal infection:
Pre-cancerous lesions
Genital warts
21. HPV Immunisation Programme 120 types of Human Papilloma Virus
35 linked to infections of genital tract
99.7% of cervical cancer caused by HPV Infection
70% caused by HPV Types 16 and 18
90% of genital warts caused by HPV Infection
HPV Types 6 and 11
22. HPV Immunisation Programme Vaccines
Cervarix (GSK)
HPV 16 & HPV 18
Gardasil (Sanofi Pasteur)
HPV 6 & 11; HPV 16 & 18
Genetically-modified yeast
High efficacy almost 100%
3 dose schedule
23. Incomplete Vaccination Histories
24. Travel Advice
25. Travel Advice
26. New Vaccines
27. Shingles
28. Rotavirus
29. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
30. Notifiable Diseases
31. Exclusions from School etc
32. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
33. Meningococcal Infection
34. Meningococcal Disease NotificationsEngland & Wales 1912-2004
35. Lab-confirmed Cases of Meningococcal DiseaseEngland & Wales 1997-2006
36. Laboratory Confirmed Cases England & Wales 96/97to 04/05
37. Case History You are working in a General Practice. A worried mother comes in saying that her child's best friend has been admitted to hospital in Glasgow with meningitis. Both children are 5 years old and attend a local primary school. She is concerned that her own family may be at risk. What would you do?
38. Case History The head teacher at the school is a patient of yours and asks for advice. What would you tell them?
39. Public Health Implications 98% cases in UK are sporadic
Close contacts most at risk
0.5% chance if no antibiotics
Household Contacts
Overnight Contacts
Equivalent Contacts
Rifampicin
Ciprofloxacin
Ceftrioxone
40. Contact Tracing
42. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
44. Epidemiology (1) Healthy carriers:
3% of healthy adults
50 to 80% of healthy newborns
16 to 35% of hospitalized patients
5 to 30% of patients in chronic care settings
Persistence in stools after infection: 10 to 40% of patients with CDAD
45. Epidemiology (2) Persistence in the environment:
Spores may persist for months!!!
Floors from CDAD patient rooms heavily contaminated
Commodes
Bed frames
Role of personnel with contaminated hands
46. Epidemiology (3) Disinfection: lack of environmentally friendly sporicidal disinfectants:
Hypochlorite 1:10 (5,000 ppm)
Hydrogen peroxide vapour (unpractical)
47. Clinical Picture Asymptomatic
3% of healthy adults
10 to 25% of hospitalized patients
5 to 70% of healthy neonates
Mild diarrhoea
Pseudomembranous colitis
Complications: toxic megacolon, perforation, death
48. PMC: Endoscopy
49. Physiopathology
50. Age
Underlying disease
Malnutrition
Hypoalbuminaemia
Chronic renal insufficiency
HIV Infection
Risk factors: Intrinsic
51. Risk factors: Extrinsic Medication:
Antibiotics
Chemotherapy
Antacids: proton pump inhibitors (???)
Medical interventions
Abdominal surgery
Nasogastric tube
Gastrostomia
Other
Duration of hospitalization
Chronic care hospitalization < 1 year
52. UHMB Cl difficile Age Breakdown
53. Control & Prevention Antibiotic constraint
(& ?PPIs)
Hand hygiene/PPE
Environmental hygiene
Isolation
54. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions
55. Information and Advice Health Protection Agency
www.hpa.org.uk
01257 246450
candlhpu@hpa.org.uk
NHS Cumbria
http://www.cumbria.nhs.uk
01768 245317
56. Information and Advice Travax
www.travax.scot.nhs.uk
Fit For Travel
www.fitfortravel.nhs.uk
NHS Immunisation Website
www.immunisation.nhs.uk
57. Suggested Topics Health Protection
Vacc & Imm
Current Schedule
MMR
BCG / New Entrants
HPV
Incomplete Histories
Travel
Possible new vaccines
Notifiable Diseases
Exclusions Meningococcal Infection
Clostridium difficile
Sources of Advice and Information
Questions