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Investigation of Bubble Formation in Tuohy-Borst Adaptors

Discovering causes of bubbles impeding blood flow in brain arteries, leading to strokes & death. Researching solutions using simulation & fluid dynamics software.

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Investigation of Bubble Formation in Tuohy-Borst Adaptors

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  1. Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements, & Jason Hirshburg Advisor: Ted Larson III, M.D. BME 272/273

  2. Introduction • Dr. Larson has 15 years of experience in interventional neuroradiology • Catheters uses: • Angiography • Embolization of arteriovenous fistulas • Aneurysms • Preoperative embolization of neck and intracranial tumors www.angiodynamics.com BME 272/273

  3. Problem • Bubbles are seen within the Tuohy-Borst Adaptor • Can get stuck in small arteries in brain, inhibiting the supply of blood and oxygen • Causes stroke and death • Once present, bubbles are difficult to remove because they stick to inner surface of system http://www.cookurological.com/products/ureteroscopy BME 272/273

  4. What is causing bubble formation? • Our task is to discover the cause and correct it • Observations: Bubbles are seen… • Stuck to inner surface of adaptor • At the edge of the Y-junction • Even before microcatheter is inserted • When catheter flow is reversed and blood hits the edge of the Y-junction and interfaces with the saline (or contrasting agent) BME 272/273

  5. Previous Work • Observed device in a medical procedure on 11/18/03 • Literature Search • Innovation WorkBench BME 272/273

  6. Current Work : Setup • Obtained tubes and adaptors to recreate Dr. Larson’s setup BME 272/273

  7. Current Work : Procedure • Adjusted pressures and valves to simulate surgery conditions BME 272/273

  8. Current Work : Results • Observed lots and lots of bubbles already present throughout the system! BME 272/273

  9. Future Work • Redesign experiments based on previous results • Simulate actual pressures (~100 mmHg for blood pressure) and temperatures (body and room) • Use actual blood • Software models of fluid flow, using Computational Fluid Dynamics (CFD) software. • Examine the effects of the differences between the two adaptor types www.ent.ohiou.edu/ ~mehta/cfd.htm BME 272/273

  10. For more information… Visit our website at http://vubme.vuse.vanderbilt.edu/srdesign/2003/group17/ BME 272/273

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