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Of vertebrae and ribs muscle of ribs , ribs, limbs

BMP-4. Somites are the most obvious evidence of the metameric, segmented, nature of vertebrates. Of vertebrae and ribs muscle of ribs , ribs, limbs meninges. A/P aspect of somitigenesis: somites from unsegmented

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Of vertebrae and ribs muscle of ribs , ribs, limbs

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  1. BMP-4 Somites are the most obvious evidence of the metameric, segmented, nature of vertebrates Of vertebrae and ribs muscle of ribs , ribs, limbs meninges

  2. A/P aspect of somitigenesis: somites from unsegmented paraxial meso. - Notch signal cycling - segmentation -regulated by FGF and other signals

  3. A/P aspect of somitigenesis: somites from unsegmented paraxial meso. - Notch signal cycling - segmentation -N->Mesp->Eph ->Ephrin->boundary

  4. A/P aspect of somitigenesis: somites from unsegmented paraxial meso. - M.E.T. occurs spatially --leads to spheres - segmentation

  5. Somite differentiation path

  6. Chick lateral/somitic frontier between primaxial and abaxial muscles between somitic and lateral-plate dermis

  7. Leave Mesoderm for a moment,GO BACK to neural crest

  8. Leave Mesoderm for a moment, GO BACK to neural crest

  9. Leave Mesoderm for a moment, GO BACK to neural crest

  10. Leave Mesoderm for a moment, GO BACK to neural crest Trunk Neural Crest migration- path 1 – anterior –Ventral -> sympath., parasympath. path 2 –posterior –Dosrolateral -> melanocytes,

  11. Leave Mesoderm for a moment, GO BACK to neural crest Four regions of N.C. 1. Cranial 2. Vagal (som.1-7) and Sacral (som. 28 - +) –parasym. Gut 3. Cardiac (som. 1-3) –aorta/P.A. 4. Trunk Symp., pigment, MedAdr

  12. Leave Mesoderm for a moment, GO BACK to neural crest

  13. Leave Mesoderm for a moment, GO BACK to neural crest • The cranial neural crest arises in the anterior and populates the face and the pharyngeal arches giving rise to bones, cartilage, nerves and connective tissue. • Other Migration Locations: • Into the pharyngeal arches and play an inductive role in thymus development. • Into the pharyngeal arches and form the parafollicular cell or ultimobranchial bodies of the thyroid gland. • Into the pharyngeal arches and play an inductive role in parathyroid gland development. • Facial ectomesenchyme of the pharyngeal arches forming skeletal muscle, bone, and cartilage in the face. • Odontoblasts (dentin-producing cells) of the teeth. • Into the optic vesicle and the developing eye and contributes to many anterior eye elements such the cornea, sclera, and ciliary muscle. It also contributes to the attaching skeletal muscles of the eye. • Into the otic placode and participates in the inner ear development. • Sensory ganglia of the fifth, seventh, ninth and tenth cranial nerves. • Schwann cells

  14. Leave Mesoderm for a moment, GO BACK to neural crest

  15. BACK to MESODERM

  16. Chick Mouse

  17. Fate of rest of splanchic mesoderm - (posterior to heart)

  18. Figure 4

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