Surveillance for Avian Influenza among Humans and Animals

1. Surveillance for Avian Influenza among Humans and Animals May, 2007

2. Learning Objectives • Understand current surveillance for avian influenza in poultry, wild birds, and humans • Understand enhanced human surveillance in response to a highly pathogenic avian influenza outbreak in poultry or wild birds

3. Presentation Overview • Federal Agencies • Human Influenza Surveillance • Routine seasonal influenza surveillance • Enhanced surveillance for Influenza A (H5N1) in humans • Animal Influenza Surveillance • Poultry • Wild Birds

4. Federal Agencies • US Department of Health and Human Services (DHHS) • CDC • US Department of Agriculture (USDA) • US Department of the Interior (DOI)

5. HHS Lead agency for avian influenza in humans • Tasks: • Pandemic influenza planning • Human surveillance • Rapid response to HPAI in humans

6. USDA Lead agency for avian influenza in poultry • Tasks: • International assistance • Import restrictions • Surveillance among domestic poultry • Rapid response to HPAI • Coordinates with states and industry

7. DOI Collaborating agency for avian influenza in wild birds • Tasks: • Surveillance among wild migratory birds • Protects health of employees and visitors on more than 500 million acres of federal lands • Rapid response to HPAI in wild migratory birds • Collaborates with USDA

8. Influenza Surveillance Among Humans

9. Routine National Surveillance • Virologic - laboratory reporting • Sentinel Providers Network • State and territorial epidemiologists reports • Emerging Infections Program • New Vaccine Surveillance Network • 122 Cities Mortality Reporting System • Influenza-associated pediatric mortality

10. Routine State-Level Surveillance • Monitor sentinel provider network data • Monitor laboratory data • Conduct mortality surveillance • Provide state-level assessments based on state-specific surveillance • Passive reporting of outbreaks in long-term care facilities and schools

11. Routine Local-Level Surveillance • Monitor local data from sentinel providers • Investigate and report influenza-related pediatric mortality • Investigate clusters of influenza-like illness (ILI) that are • a) outside of regular flu season, or • b) in nursing homes or healthcare facilities • c) unusually severe • Area-specific activities

12. Local Surveillance During Pandemic Alert Continue routine surveillance activities AND • Investigate cases of respiratory illness with epidemiologic risk factors (following CDC case definition) • Investigate clusters of respiratory illness that are socially or occupationally linked • Investigate unusually severe respiratory illnesses • Facilitate laboratory testing for person(s) meeting these criteria

13. CDC Guidance for the Current Situation: Enhanced Surveillance Testing for avian influenza A (H5N1) virus infection is recommended for: A patient who has an illness that: • Requires hospitalization or is fatal; AND • Has or had a documented temperature of ≥38°C (≥100.4° F); AND • Has radiographically confirmed pneumonia, acute respiratory distress syndrome (ARDS), or other severe respiratory illness for which an alternate diagnosis has not been established; AND • Has at least one of a list of potential exposures within 10 days of symptom onset:

14. CDC Guidance: Exposures Exposures to investigate if within 10 days of illness onset: • History of travel to a country with influenza H5N1 documented in poultry, wild birds, and/or humans, AND had at least one potential exposure (i.e. sick poultry) during travel http://www2a.cdc.gov/han/ArchiveSys/ViewMsgV.asp?AlertNum=00246 • Close contact (approach within 3 feet) of an ill patient who was confirmed or suspected to have H5N1 • Worked with live influenza H5N1 virus in a laboratory

15. Case by Case Considerations • Mild or atypical disease (hospitalized or ambulatory) with one of the specific exposures listed • Severe or fatal respiratory disease whose epidemiological information is uncertain, unavailable, or otherwise suspicious but does not meet the criteria listed

16. Enhancing Local Surveillance • Enhance surveillance and record review in hospitals • Public Service Announcements • Telephone hotlines • Door-to-door investigations • Occupational surveillance

17. Goals of Human Surveillance for Pandemic Influenza • Detect initial cases of pandemic strain • Track introduction of virus to local areas • Monitor changes in virus • Early warning of increased illness in community • Monitor health effects of pandemic • Track trends in disease activity

18. Human Surveillance Upon confirmed HPAI in animal species… • Conduct active case finding • Assess exposures • Classify and test potential cases

19. 1. Active Case (and Contact) Finding • Everyone with known or possible exposure 72 hours before bird symptoms • Known or possible exposures • Infected poultry • Under- or uncooked infected poultry • Infected wild or pet birds • Manure and litter • Contaminated surfaces, vehicles, equipment, etc • Contaminated air space • Within 3 ft of infected person

20. 2. Exposure Assessment • Characterize exposures • Define target population • Most likely to be exposed • Those involved in HPAI control and eradication • Poultry farm owners or employees, state and federal animal health agency employees • Special consideration—unprotected exposure • Undertake contact tracing

21. 3. Classify and Test • Classify the persons with severe or fatal respiratory disease as: • Suspect Case • Confirmed Case • Report Under Investigation • Not a Case • Report internationally using WHO case definition • States report to CDC • CDC/HHS report to WHO/PAHO • Perform laboratory testing

22. Proposed Influenza Division/CDC Case Definitions • Confirmed • Suspect • Report under investigation • Non-case • To be used for reporting purposes • A separate CDC Health Alert Network was released that includes criteria for who should be tested for Influenza A (H5N1) • Definitions may be modified for specific outbreaks

23. Proposed Influenza Division/CDC Case Definitions Confirmed Case (symptoms, exposure, laboratory confirmation) • Documented temperature >38 C (>100.4 F) and one of the following: cough, sore throat, and/or respiratory distress AND • One of the following exposures within 10 days of onset • Direct exposure to sick or dead domestic poultry • Direct exposure to surfaces contaminated with poultry feces • Consumption of raw or partially cooked poultry or poultry products • Close contact (within 3 feet) of an ill patient with confirmed or suspected avian influenza A (H5N1) infection • Works with live HPAI (H5N1) virus in a laboratory AND…

24. Proposed Influenza Division/CDC Case Definitions Confirmed Case (Continued) • Positive for avian influenza A (H5N1) virus by one of the following methods • Isolation of H5N1 from viral culture • Positive RT-PCR for H5N1 • 4 fold rise in H5N1 specific antibody titer by microneutralization assay in paired sera • Positive IFA for H5 antigen using H5N1 monoclonal antibodies

25. Proposed Influenza Division/CDC Case Definitions Suspect Case • Documented temperature >38 C (>100.4 F) and one of the following: cough, sore throat, and/or respiratory distress AND • One of the following exposures within 10 days of onset • Direct exposure to sick or dead domestic poultry • Direct exposure to surfaces contaminated with poultry feces • Consumption of raw or partially cooked poultry or poultry products • Close contact (within 3 feet) of an ill patient with confirmed or suspected avian influenza A (H5N1) virus infection • Works with live HPAI (H5N1) virus in a laboratory • Laboratory test for avian influenza A (H5N1) is pending, inadequate or unavailable

26. Proposed Influenza Division/CDC Case Definitions • Report Under Investigation • Additional information needed on clinical and exposure information • Not a Case • Negative avian influenza A (H5N1) virus testing result from a sensitive laboratory testing method using adequate and appropriately timed clinical specimens

27. Poultry Outbreak and Human Surveillance Activities • Apply outbreak case definitions • Disseminate case definition • Health Alert Network (HAN) • Epi-X • Create and disseminate outbreak reporting questionnaire • Consider database and reporting tools • Identify and interview potential cases and contacts

28. Surveillance Activities cont. • Conduct surveillance for human illness linked to affected premises • Ensure timely reporting of cases to CDC • Characterize seasonal influenza strains • Notify other states that might receive cases or contacts • Advise contacts to monitor symptoms daily for 10 days post-exposure • Assign person to actively monitor exposed persons

29. Definition of Close Contacts The definition of close contact is household and other contacts in work, school, and community settings who had close unprotected (i.e., not wearing PPE) contact in the 1 day before through 14 days after the case patient’s symptom onset. Examples of close contact (within 1 meter) with a person include providing care, speaking with, or touching. * http://www.who.int/csr/resources/publications/influenza/WHO_CDS_EPR_GIP_2006_4r1.pdf * Depending on the specific circumstances suspect or confirmed cases that have completed isolation for at least 7 days, and who are no longer symptomatic, may not be considered a source of exposure to others.

30. Potentially exposed persons • Poultry workers • Agriculture responders • Farmers • Veterinarians • People purchasing raw/undercooked poultry products • Farm visitors • Travelers

31. Possible Contacts of Suspect and Confirmed Cases • Healthcare workers • Family members • Emergency Medical Services staff

32. Recommendations for Contacts • Self-monitor for symptoms for 10 days after last exposure • Evaluate for antiviral prophylaxis • Adhere to infection control procedures If symptoms develop, reclassify according to case definitions

33. Influenza Surveillance Among Animals

34. Animal Surveillance Poultry: • Live bird markets • Commercial flocks • Backyard flocks Other Birds: • Imported birds • Wild birds • Pet birds

35. Notifiable AvianInfluenza (NAI) “Avian influenza in its notifiable form (NAI) is defined as an infection of poultry caused by any influenza A virus of the H5 or H7 subtypes or by any AI virus with an intravenous pathogenicity index (IVPI) greater than 1.2 (or as an alternative at least 75% mortality) as described… NAI viruses can be divided into highly pathogenic notifiable avian influenza (HPNAI) and low pathogenicity notifiable avian influenza (LPNAI)”

36. Markets • Licensing • Bird testing and recordkeeping • Sanitation and biosecurity • Surveillance • Response

37. Live Bird Markets • Prevent and control LPAI • Markets • Production facilities • Distributors • Regular monitoring and surveillance of all facilities in volunteer states • Quarterly random testing • Quarterly closure with depopulation, cleaning, disinfection and down time • State-level monitoring in non-participating states

38. Commercial Flocks National Poultry Improvement Plan (NPIP) • USDA program • Monitor poultry production facilities • Systematic testing of flocks • Test all ill birds • Coordinate with states for response and containment plans

39. Surveillance: NPIP On-farm • Establishes standards for evaluation of poultry breeding stock and hatchery products • “Avian influenza free” certification for commercial companies http://www.aphis.usda.gov/vs/npip/

40. Surveillance: NPIP (cont.) • New LPAI program that will provide for H5 and H7 AI monitoringand indemnity for LPAI. • Program components: • “AI monitored” program • Surveillance specifications • State LPAI response and containment plans

41. Domestic, Non-Commercial Backyard Flocks • “Biosecurity for the Birds” program • Report sick birds to an animal health professional • Practice biosecurity • Collaborators • State Departments of Agriculture • USDA Cooperative Extension Service • Private veterinarians

42. Imported Birds • USDA mandates quarantine and testing all imported birds for avian influenza • Poultry • Pet birds • Zoo birds • Ratites (i.e. ostriches and emus) • Current ban on live or fresh birds or poultry from areas where the Asian strain H5N1 virus exists

43. Wildlife Surveillance Five components to surveillance • Investigation of morbidity and mortality • Surveillance in live wild birds • Surveillance in hunter-killed birds • Sentinel species monitoring • Environmental sampling

44. Wild Bird Surveillance – The USG Interagency Strategic Plan • Part of the President’s National Strategy for Pandemic Influenza • Partnership among: • U.S. Departments of Agriculture, Interior, Health and Human Services • Association of Fish and Wildlife Agencies • National Association of Public Health Veterinarians • State agencies • Unified national system for early detection of highly pathogenic H5N1 AI in wild birds. Provides standard procedures and strategies for sampling, diagnostics and data management. • Serves as a guide for regional and state surveillance plans.

45. Migratory Birds • Capture, sample, test • Monitor and test wild birds • Alaska / Pacific flyway • Mississippi (Central) flyway • Atlantic flyway • Collaborators: DOI, USDA, USGS, US Fish and Wildlife, state agencies, and others

46. Case Definition for Poultry • Surveillance at the flock level, rather than individual level (as in human surveillance) • Clinical case definition of HPAI in poultry flocks • Symptoms of illness such as drops in egg production, lack of energy and appetite, nasal discharge, lack of coordination, swollen head and legs AND/OR • Unusual mortality

47. Diagnostic Testing in Poultry • Rapid screening test: RT-PCR • Identifies H5 or H7 viruses • Available within 4-7 hours • Confirmation by National Veterinary Services Laboratory (NVSL) • Confirmatory testing: viral isolation • Genetic sequencing • Pathogenicity test • Available within 5-10 days of receipt

48. LPAI Surveillance – National Animal Health Laboratory Network (NAHLN) Labs • More than 45 laboratories participate in the network. NAHLN labs: • Provide laboratory services nationwide • Provide laboratory data for reporting • Respond to foreign animal disease outbreaks • Focus on animal diseases

49. Presumptive Positive in Poultry • Sudden and significant increase in mortality • With clinical signs - or - • Post mortem lesions - and - • Decrease in egg production • Positive RT-PCR for H5 or H7 • From NVSL, NAHLN, or other USDA-approved lab

50. Reporting HPAI in Poultry • Reporting varies by state • Industry • Backyard flocks • H5 or H7 LPAI • Presumptive positive cases reported to USDA or DOI will be immediately reported to: • OIE (World Organization for Animal Health) • Trade partners • Other Federal agencies • States • Industry