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PhD. student kefah F.Hasson 2014

Hypersensitivity Reactions type III. PhD. student kefah F.Hasson 2014. Type III Reactions: other name : Immune Complex . Involve reactions against soluble antigens circulating. Usually involve IgA antibodies.

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PhD. student kefah F.Hasson 2014

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  1. Hypersensitivity Reactions type III PhD. student kefah F.Hasson 2014

  2. Type III Reactions: • other name : Immune Complex . • Involve reactions against solubleantigens circulating. • Usually involve IgA antibodies. • Antibody-Antigen immune complexes are deposited in organs, activate complement, and cause inflammatory damage.

  3. Mechanism of type III hypersensitivity • Formation of the intermediate immune complex • Deposition of theintermediate immune complex • Tissue injury by the immune complex.

  4. Immune Complex Mediated Hypersensitivity .

  5. Common Disease of type III Hypersensitivity Arthusreaction : local immune complex reaction may cause Necrotic vasculitis, Ulcer.

  6. Complement initiates mast cell degranulation • Neutrophils are chemotactically attracted to the site • Neutrophils release lytic enzyme after failed attempts to endocytose the immune complex

  7. Serum Sickness  Disease: (SSD) • Acute systemic immune complex in tissue may cause fever, skin rash ,erhythema . • due to Penicillin、Sulfanilamide • Acute immune complex glomerulonephritis (locally) : • due to Streptococcus infection . • Glomerulonephritis: Inflammatory kidney damage. • Occurs with slightly high antigen-antibody ratio is present.

  8. Serum sickness

  9. Chronic immune complex disease • Systemic Lupus Erythematosus (SLE): • Auto -antibodies react against DNA, blood cells, neurons, and other tissues. • When cells die, immune complexesform and deposit under skin, joints, in kidneys, blood vessels, and central nervous system. • Rheumatoid Arthritis: auto -antibodies (rheumatoid factors) against IgG form complexes in joint, leading to inflammation and cartilage damage. Often causes finger and joint deformities.

  10. Systemic Lupus Erythematosus

  11. THANK YOU

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