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Zohora Iqbal PhD student

Zohora Iqbal PhD student. My Education Path. My Education Path. Undergraduate Las Positas /Chabot College (2.5 years) UC Berkeley (2.5 years) Working at start-up Ion Torrent (1 year) Graduate School UC Berkeley and UC San Francisco combined graduate program (current). B ioengineer.

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Zohora Iqbal PhD student

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  1. Zohora Iqbal PhD student

  2. My Education Path

  3. My Education Path • Undergraduate • Las Positas/Chabot College (2.5 years) • UC Berkeley (2.5 years) • Working at start-up • Ion Torrent (1 year) • Graduate School • UC Berkeley and UC San Francisco combined graduate program (current)

  4. Bioengineer amyris.com

  5. Bioengineering Research at Berkeley • Bioinstrumentation • imaging: MRI  imaging near metal implants • diagnostic tools: micro/nano scale protein analysis • bioMEMS: microfabricated devices • Microfluidics, drug delivery systems • artificial organs • Biomaterials and Nanotechnology • biomimetics • surface coating for implants • Cell and Tissue Engineering • Stem cells • single cell studies to better understand cellular systems • Computational Biology • dna and protein data analysis. • producing models of proteins or biomolecules • Systems and Synthetic Biology • controlling microbes to produce desired molecules such as insulin…fuels, plastics..etc. medication.. https://www.youtube.com/watch?v=_i-_1QdY2Zc

  6. Undergraduate Research Experiences • Sandia National Lab in Livermore • microfluidics: single cell macrophage studies • picoliter reaction chambers • Virginia Tech: Davalos Lab • simulation of devices for cancer cell separation • UC Berkeley: Herr Lab • on-chip protein separation based on isoelectric point

  7. Working at Ion -array of wells -each one holds a bead with thousands of single stranded DNA -nucleotide flows over it, and if one gets incorporated, H+ released, and so by measuring the pH

  8. Why PhD? • More opportunities • especially in the bioE field…lot of work going on in research • easier to lead your own project:

  9. Rotations • Roy Lab • lung project • Maharbiz Lab • Miniaturized Tesla turbine • Herr Lab • protein separation • PICKED ROY LAB: Artificial Kidney

  10. Kidney

  11. Nephron • cleans out toxins and excess substances from blood • filtration based on size driven by blood pressure • reabsorption of necessary nutrients, solutes and water via active and passive transport

  12. End Stage Renal Disease • ESRD: complete or near complete loss of kidney function, often due to diabetes and/or hypertension • Current treatment: • kidney transplant • hemodialysis • typically done ~3x/week using external diffusion driven dialysis system • peritoneal dialysis • patient’s own pertoneum in diffusion driven filtration

  13. ESRD Statistics • Data from 2010 • more than ~170,000 new ESRD patients added • prevalence: ~0.6 million • total kidney transplants: 17,778 • total Medicare ESRD expenditure: $33 billion • total ESRD expenditure: $47.5 billion

  14. Artificial Kidney • 2 parts: filtration and reabsorption • filtration based on size • reabsorption bioreactor • use of silicon membrane • why silicon? • uniformity  high selectivity • robustness • ease of fabrication through MEMS technology • mass production • high throughput given area

  15. Silicon Membrane • Pore Size: • long slits • pore length: 4.5 um • pore height: 13 nm pore • pore width: 40 um

  16. Biofouling -Cells and proteins attach to surface limiting filtration

  17. polySBMA surface coating BrTMOS initiator SBMA Silicon

  18. Key Points • Be a team player • Know how to avail the resources you have • Learn how to learn: be willing to learn new materials

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