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PDGF

MAP Kinase. Erk. c-fos. c-jun. PDGF. PDGFR. Raf-1. mSos. MEK. Ras. Grb2. PI3K. Rac. Rho. Actin Reorganization. Mitogenesis. Figure 1. - + +. + + + + + + + +. 205. PDGF b R. 116. 97. 66. 1 2 3. 4 5 6 7 8 9 10 11. Balb. B+K.

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PDGF

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  1. MAP Kinase Erk c-fos c-jun PDGF PDGFR Raf-1 mSos MEK Ras Grb2 PI3K Rac Rho Actin Reorganization Mitogenesis Figure 1.

  2. - + + + + + + + + + + 205 PDGFbR 116 97 66 1 2 3 4 5 6 7 8 9 10 11 Balb B+K Balb membranes plus fractions mM NaCl 0 115 205 295 385 475 565 655 PDGF-BB Figure 2.

  3. + + + a-Syp - - 0 205 295 0 205 295 mM NaCl - + + + + + + + PDGF-BB 200 PDGFbR 97.4 68 1 2 3 4 5 6 7 8 Figure 3.

  4. A B C D Figure 4.

  5. Cell type VO4 PDGF-bR kinase activity Phenotype Untransformed fibroblast Balb - + Untransformed fibroblast Balb - + Transformed fibroblast KBalb + - KBalb + + Fibroblast-like Table 1. Preatment of Balb and Kbalb cells with sodium vanadate prior to PDGF-BB stimulation: Correlation with PDGF-bR kinase activity and cell phenotype.

  6. FAK P PI3K T V Ras a Ras Pak Rac MAPK ROK Rho cascade Figure 5.

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