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PDGF receptor beta and Leukemia By Will Turbyfill

PDGF receptor beta and Leukemia By Will Turbyfill. An RTK. Hoch, et al. 2003. A Family of Proteins. Borkham-Kamphorst, et al. 2005. Hoch, et al. 2003. Ras Pathway Activation. Hoch, et al. 2003. Critical Role in Angiogenesis. Hoch, et al. 2003. Critical Role in Angiogenesis.

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PDGF receptor beta and Leukemia By Will Turbyfill

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  1. PDGF receptor beta and Leukemia By Will Turbyfill

  2. An RTK Hoch, et al. 2003

  3. A Family of Proteins Borkham-Kamphorst, et al. 2005 Hoch, et al. 2003

  4. Ras Pathway Activation Hoch, et al. 2003

  5. Critical Role in Angiogenesis Hoch, et al. 2003

  6. Critical Role in Angiogenesis Hoch, et al. 2003 Null Mutants Die Perinatally

  7. Glomerulogenesis Hoch, et al. 2003

  8. Glomerulogenesis Hoch, et al. 2003 Also plays a role in retinopathy

  9. So What’s Going Wrong?

  10. So What’s Going Wrong?

  11. Myeloproliferative Disorders Cross, et al. 2002

  12. Myeloproliferative Disorders Cross, et al. 2002 Translocations involving PDGFR beta lead to Chronic Myelomonocytic Leukemia (CMML).

  13. Translocations join kinase to constitutively active proteins CMLSupport.com

  14. Translocations join kinase to constitutively active proteins Philadelphia Chromosome is the most common translocation in CML CMLSupport.com

  15. PDGFR beta translocations similar to Bcr-Abl Cross, et al. 2002

  16. PDGFR beta translocations similar to Bcr-Abl Cross, et al. 2002

  17. PDGFR beta translocations similar to Bcr-Abl Cross, et al. 2002

  18. Constitutive Dimerization Activates Receptor

  19. Constitutive Dimerization Activates Receptor Cross, et al. 2002

  20. Constitutive Dimerization Activates Receptor Cross, et al. 2002

  21. Constitutive Dimerization Activates Receptor Cross, et al. 2002

  22. Constitutive Dimerization Activates Receptor

  23. Possible Therapy: Imatinib Wilkepedia.org

  24. Bibliography Borkham-Kamphorst, E., Meurer, S., Gressner, A., Weiskirchen, R. Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells. Biochemical and Biophysical Research Communications 2005; 338: 1711-1718. Http://www.cmlsupport.com. 2003. 3/19/2006 Cross, NCP., Reiter, A. Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 2002; 16: 1207-1212. Hoch, R., Soriano,P. Roles of PDGF in animal development. Development 2003; 130: 4769-4784. Http://www.wilkepedia.org. Imatinib. 3/19/2006

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