Interdisciplinary Biomedical Engineering Research at the University of Florida

1. Interdisciplinary Biomedical Engineering Researchat theUniversity of Florida

2. College of Engineering at a Glance • 275 faculty, 4600 undergraduate students, 1900 graduate students • 900 BS, 600 MS, 140 PhD per year • $90M research expenditures • 11 academic departments • Engineering in biology and medicine • New Department of Biomedical Engineering – July 2002

3. Evolution into Epilepsy • Researchers from the • College of Engineering, • the College of Medicine and • the Department of the Navy • are working together to find a method of predicting and controlling epilepsy-triggered seizures. • The NIH recently awarded the team a $1.4, 4-year grant. • [PI: Dr. William L. Ditto • NIH 1R01EB004752-01]

4. Evolution into Epilepsy:A dream team of researchers from the University of Florida and Shands at UF. • Dr. William L. Ditto, PI — Biomedical Engineering • Dr. Paul R. Carney — Pediatric Neurology • Dr. Thomas B. DeMarse — Biomedical Engineering • Dr. Thomas Mareci — Biochemistry & Molecular Biology • Dr. J. Chris Sackellares — Biomedical Engineering • Dr. Justin C. Sanchez — Pediatric Neurology • Dr. Mark C. Spano — Department of the Navy • Michael D. Furman — Biomedical Engineering • Jennifer Simonotto — Biomedical Engineering

5. Evolution into Epilepsy brain / animal image data raw data EEG / histology analysis mea data Slice

6. Brain Dynamics Bioengineering Research Partnership • The mission of the Brain Dynamics Bioengineering Research Partnership is to develop an online, real-time automated seizure warning and prevention system for use by epileptic patients and their caregivers.  • [PI: Dr. J. Chris Sackellares • NIH NIBIB R01EB002089]

7. Brain Dynamics Bioengineering Research Partnership • Dr. J. Chris Sackellares, PI • Biomedical Engineering • Dr. Paul R. Carney • Pediatric Neurology • Dr. Panos M. Pardalos • Industrial & Systems Engineering • Dr. José C. Principe • Electrical & Computer Engineering • Dr. Deng-Shan Shiau • Neuroscience • Dr. Mark C. Yang • Statistics • Dr. Leonidas D. Iasemidis • Arizona State University

8. Optical Imaging of Breast Cancer • Huabei Jiang, a widely known innovator in the field of optical imaging, is supported by a 5-year, $1.4 million grant awarded to him in 2002 by the National Institutes of Health. • He's developing a relatively painless, non-invasive technique to detect breast cancer. Instead of allowing their breasts to be compressed between two plastic plates and held firmly in place, as in a mammogram, patients in Jiang's study lie face down on a special exam table. An array of fiber optics gently surround the breasts and project near-infrared light at different angles • Dr. Huabei Jiang, PI • Biomedical Engineering • Stephen Grobmyer • Department of Surgery • [NIH R01CA090533]

9. Monitoring Intraperitoneal Bleeding • Bleeding in the abdominal cavity is a frequent consequence of the blunt trauma suffered in motor vehicle accidents. Often it is undetected by conventional clinical screening techniques. Rosalind Sadleir’s group has developed a monitoring method that can quantify the rate of bleeding and thus the urgency of surgery. Now, they’re readying a new commercial device for clinical trial. • Dr. Rosalind Sadleir, PI • Biomedical Engineering • Dr. Edward Ross • Medicine (Nephrology)

10. Advanced Magnetic Resonance Imaging and Spectroscopy Facility • AMRIS is a state-of-the-art NMR facility for high-resolution solution NMR, solid-state NMR, microimaging, animal imaging and human imaging. • AMRIS currently has seven spectrometer systems, including a 750 MHz wide bore, an 11 T/40 cm bore horizontal animal imaging magnet, and two 3T human systems. AMRIS was developed in part through a grant from the Department of Defense. An external users program in AMRIS is supported by the National High Magnetic Field Laboratory through funds from the National Science Foundation. • Dr. Arthur Edison, Director

11. Advanced Magnetic Resonance Imaging and Spectroscopy FacilityFaculty at the University of Florida • Dr. Steve Blackband — Neuroscience • Dr. C. Russell Bowers — Chemistry • Dr. Ioannis Constantinidis — Medicine • Dr. Bruce A. Crosson — Clinical & Health Psychology • Dr. Arthur Edison — Biochemistry & Molecular Biology • Dr. Jeffrey R. Fitzsimmons — Radiology • John Forder — Radiology • Huabei Jiang — Biomedical Engineering • Dr. Peter Lang — Clinical & Health Psychology • Dr. Yijun Liu — Psychiatry • Dr. Joanna Long — Biochemistry & Molecular Biology • Dr. Thomas Mareci — Biochemistry & Molecular Biology • Ilona Schmalfuss — Radiology • Krista Vandenborne — Physical Therapy • Glenn Walter — Physiology • Norbert Wilke — Radiology (Jacksonville)

12. Biomaterials Research • Bio-erodable Micro-porous Polysaccharide Foams Scaffolds • Spinal Cord Regeneration in rats using a Combination of Polymer Scaffolding and Microglia Cells • Research supported by the Christopher Reeves Foundation • Goldberg (Materials Science) and Streit (MBI)

13. Gross view (a) and (b) represent dorsal views and (c) represents coronal section -5 1.5x10 300K -5 1.0x10 -6 5.0x10 0.0 -6 Magnetization(emu) -5.0x10 -5 -1.0x10 -5 -1.5x10 -1000 -750 -500 -250 0 250 500 750 1000 H(Gauss) Nano-particles for Medical Applications • A specially designed particle, quantum dot based contrast agent, • that is paramagnetic, fluorescent, and radio-opaque • Potentially useful as a biomarker for imaging and surgery • Santra (PERC), Moudgil (MSE, PERC), Holloway (MSE), Mercle (Neurosurgery), Walter (Neurosurgery) Fluorescent Radio-opaque Paramagnetic

14. Brain Machine InterfacesUF Collaboration with Duke and MIT • The CNEL Lab (Principe, Harris) designs models which “decode” neuronal activity into motor commands for prosthetics • Models are implemented in low power, hybrid (analog VLSI-DSP) chips

15. IT for Medical Applications • Assistive Environments for Successful Aging (GatorTech Smart House) • Radiation Treatment and Planning - Dose computation, Leaf sequencing • Medical Imaging • Bioinformatics • Preserving a `Hands-on’ Knowledge Base of Essential but Rare Surgical Procedures

16. Interdisciplinary Bioimaging & BioengineeringBuilding • The proposed facility will house and integrate the biomedical-focused groups within one 275,000 square foot building to create completely new research and funding opportunities. • The physical and cultural integration of researchers within this building will provide synergistic and collaborative environments that will establish UF as a leader in interdisciplinary biomedical science, engineering, technology, translational research and technology transfer. A state-of-the-art animal care facility in the same building will add to the synergy and allow UF researchers access to the finest biomedical research infrastructure in the world.

17. Interdisciplinary Bioimaging & BioengineeringBuilding • Biological Imaging Center • [70,000 sq. ft.] • Clinical translational research • Technology Liaison Office • Structural Biology and Molecular Biophysics • Brain Research Labs • [50,000 sq. ft.] • New programs for brain/neuroscience • Department of Biomedical Engineering • [75,000 sq. ft.] • Administrative offices • Research labs • Animal Care Facility • [62,000 sq. ft.] • Support Programs & Public Space • [18,000 sq. ft.]