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Biomedical Engineering Research at UNL Opportunities

Biomedical Engineering Research at UNL Opportunities. Contacts:. Namas Chandra, Ph.D. P.E . Associate Dean-Research College of Engineering (402) 472-8310 nchandra2@unl.edu. Becky Dole Technical Assistant (402) 472-5600 bdole2@unl.edu. Computations. Biology. Human Behavior. Physics.

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Biomedical Engineering Research at UNL Opportunities

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  1. Biomedical Engineering Research at UNL Opportunities Contacts: Namas Chandra, Ph.D. P.E. Associate Dean-Research College of Engineering (402) 472-8310 nchandra2@unl.edu Becky Dole Technical Assistant (402) 472-5600 bdole2@unl.edu

  2. Computations Biology Human Behavior Physics Chemistry Medicine Health Mathematics • Novel • Biomaterials • Implants • Devices • Instruments • Informatics • Better health • Improved diagnostics • Longer life • Faster rehabilitation What is Biomedical Engineering?

  3. Areas of Expertise • Tissue Mechanics (engineering) • Mechanical, Engineering Mechanics, Chemical, and Biomolecular • Medical Devices (surgical or otherwise) • Mechanical, Engineering Mechanics, Industrial • Biomechanics/Rehabilitation • Mechanical, Engineering Mechanics, Industrial • Image Analysis/Pattern Recognition • Computer Science and Engineering

  4. Multifunction Tool forMinimally Invasive Surgery (MIS) Goal: Eliminate frequent tool changes in MIS that waste valuable OR time and cause unnecessary trauma to patients Solution: Multifunction tool; fuzzy logic guides preoperative tool setup UNL: Carl Nelson UNMC: D. Oleynikov Infant Surgical Table Goal: Allow infant retinal surgery to be performed while seated with full rotation and tilt controls Solution: Attachment for full-size surgical table; novel anticrimp attachments for hoses; adjustable safety-lock clamp UNL: Carl Nelson UNMC: T. Hejkal Mechanical Devices

  5. Tissue Mechanics and New Ideas • Tissue Mechanics • Obtain mechanical properties • Concerned with shear behavior, not just axial stress-strain • Developing a very small measurement fixture UNL: Carl Nelson UNMC: J. Hammel Test Set-up • Make surgery easier, more effective, and more accessible • Tool tracking in minimally invasive surgery • Modular surgical robots • Custom tools for tasks that are repetitive and mechanically difficult/time consuming

  6. Miniature In Vivo Robots for Surgery • Better • Miniaturized robots function entirely within the body • Access to more surgical sites and organs • Improved visualization • Reduced incisions • Faster • Limited set-up time • Additional tools can be added or removed quickly • Cheaper • Mass produced • Nor hardware infrastructure (laptop enabled) • Disposable UNL: Shane Farritor UNMC: Dmitry Oleynikov

  7. In Vivo Robots-Details Mobile Camera Pan/Tilt Camera Biopsy

  8. Porcine In Vivo Mobility

  9. Worldwide Abundant Recombinant Hemophilia Therapy Made in the Milk of Transgenic Pigs: Pharmacokinetic Properties for Intravenous and Oral Delivery Evaluated in Hemophilic Animals Investigating Team William H. Velander, Kevin E. Van Cott, Todd Swanson Dept of Chemical and Biomolecular Engineering University of Nebraska-Lincoln, Lincoln, NE Stephan Butler and Julian Cooper, Progenetics LLC, Pembroke, VA Paul E. Monahan, Gene Therapy Center University of North Carolina at Chapel Hill, NC Oral Alpan and Polly Matzinger, NIH/NIAID, Bethesda Maryland Diverse Funding Source and Timeline National Science Foundation Commonwealth of Virginia American Red Cross NIH/NIAD Progenetics LLC Ministry of Brazil Indian Department of Biotechnology 1987-------------1998 Fundamental studies 2004-------------2007 Preclinical 2007-------------2010 Clinical

  10. Complex Recombinant Protein Production Process Recombinant Protein in Milk Pig Chromosome with Milk Production Gene through cloning or microinjection Transgenic Pig High Purity Biologic formulation: Intravenous, Oral, Buccal, IN, IT Delivery Large Scale Purification Process Executive Council Meeting

  11. Nano Touch SensorsRavi Saraf, Chemical Engineering, rsaraf@unl.edu Resolution is 20 mm which is 2-fold smaller than human finger; and 100 fold smaller than the current Electronic MEMS devices. Disphering cancer by texture: The surgeon has a resolution of our sensor is ~20 mm. Giving surgeon the sensation of human touch during minimally invasive procedure: Saraf, UNL 2006 rsaraf@unlnotes.unl.edu Executive Council Meeting

  12. (c) (d) (f) (e) Single Electron Nanodevice to Measure Electrochemical Activity in a Single Cell Ravi Saraf, Chemical Engineering, rsaraf@unl.edu • Combinatorial microarray with low false positive:Using the necklace as nano-electrode and combining with our combinatorial electrochemistry device, will allow us to measure perform microarray analysis using cells as the transduction agency. • Live Bio-transistor:Use cell as a gating device to make electronics that is “intelligent” and “adaptable”. • Power generation:Use the charge production form the cell (such as ATP cycle) to convert food directly to electricity. Executive Council Meeting

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