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Feeding Pathways

Feeding Pathways. Hunger vs. Satiety. Controlled by communication between the gut and p arasympathetic nervous system. Neuroscience (Bears, Connors, Paradiso ). Some Basic Feeding Terminology. Feeding Behavior:

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Feeding Pathways

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  1. Feeding Pathways

  2. Hunger vs. Satiety Controlled by communication between the gut and parasympathetic nervous system Neuroscience (Bears, Connors, Paradiso)

  3. Some Basic Feeding Terminology • Feeding Behavior: • Hyperphagy:increase in food intake (often used to explain pathological eating) • Hypophagy: decrease in food intake • Feeding Physiology: • Orexigenic: release of a drug or hormone that increases food intake • Anorexigenic: release of a drug or hormone that decrease food intake

  4. Peripheral Regulation of Food Intake • Leptin (anorexigenic; satiety) • Ghrelin (orexigenic; hunger)

  5. Dysregulation of leptin leads to… • The ob/ob mouse: do not have circulating leptin levels, but this does not mean that they are insensitive to leptin • In fact, they are hypersensitized to exogenously administered leptin. WHY? • animal model of Type II diabetes

  6. Central Regulation of Food Intake The BIG THREE hypothalamic areas regulating food intake are: Lateral hypothalamus Ventromedial hypothalamus Arcuate Nucleus

  7. Central Regulation of Hyperphagy • NPY/AgRP-containing enhance feeding behavior

  8. Central Regulation of Hypophagy • αMSH/CART-containing inhibit feeding behavior

  9. Balance Between Two Pathways • Competitive agonism of MSH receptors and antagonism of MC4 receptors by leptin

  10. Central Regulation of Thirst • Communication between neurons in the pituitary (organumvasculosum of lamina terminalis [OVLT] and vasopressin-secreting neurons) and kidneys • Diabetes Insipidus

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