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Narcolepsy

Narcolepsy . Kelly Lewis Jimmy Wells Stacey Leonard. Narcolepsy. Frequent disorder the second leading cause of excessive daytime sleepiness after obstructive sleep apnea Epidemiology of narcolepsy an incidence of 0.2 to 1.6 per thousand in European countries, Japan and the United States.

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Narcolepsy

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  1. Narcolepsy Kelly Lewis Jimmy Wells Stacey Leonard

  2. Narcolepsy • Frequent disorder • the second leading cause of excessive daytime sleepiness after obstructive sleep apnea • Epidemiology of narcolepsy • an incidence of 0.2 to 1.6 per thousand in European countries, Japan and the United States. • a frequency at least as large as that of Multiple Sclerosis.

  3. NarcolepsySociological Impact • Disabling • work • leisure • interpersonal skills • accident prone • Under-diagnosed • majority of patients in country are still undiagnosed • the mean number of years between the onset of symptoms and correct diagnosis was 14 years

  4. NarcolepsySymptoms • EDS - Excessive Daytime Sleepiness • Abnormal REM Sleep • Cataplexy • Sleep Paralysis • Hypnagogic Hallucinations

  5. NarcolepsyDiagnosis • Diagnosis through specific medical procedures easy if symptoms are present • Nocturnal Polysomnogram • Multiple Sleep Latency Test (MSLT) • will confirm the daytime sleepiness by showing a short sleep latency of usually less than 5 minutes, as well as an abnormally short latency prior to the first REM period (SOREMPs).

  6. Narcolepsy Genetics • Due to modern technology, accurate diagnosis can occur, but the cause of Narcolepsy is still unknown • We do know it has a strong genetic base and it involves the immune defense system • The gene is close to being discovered and the cure will soon follow • Narcolepsy gene studies have involved narcoleptic Doberman pinschers

  7. NarcolepsyGenetics • The results of a family study were consistent with a dominant mode of inheritance with incomplete penetrance of a hypothetical disease susceptibility gene • Most cases of narcolepsy have no other family members affected with narcolepsy and the risk is very small. If you have narcolepsy-cataplexy, the risk for your child to develop narcolepsy-cataplexy is only 1-2%. The risk of developing daytime sleepiness without cataplexy may be slightly higher (4%).

  8. NarcolepsyPedigree

  9. NarcolepsyReferences Cure Narcolepsy Now www.users.cloud9.com/~thorpy/narc.html Stanford Center for Narcolepsy www-med.stanford.edu/school/Psychiatry/narcolepsy/

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