CENG 109 Biotechnology and Its Business Opportunities Class 1

1. AnnouncementStudents from Engineering School: pick up a Red cardStudents from Science School: pick up a cardStudents from Business School/Dual Degree Program: pick up a Blue card White CENG 109 Biotechnology and Its Business Opportunities Class 1

2. Outline of this class • Course matters • Course perspectives • Grouping exercise • Review jargons in biological information • PRS demonstration • Course preview

3. CENG 109 Teaching Staffs • Instructor: Prof. Ying Chau (keychau@ust.hk) Office hours: Tuesday 9-10a (by appointment) Rm 4551 • Teaching assistants: • Yuki (zhongy@ust.hk) • Cassie (joleeli@ust.hk) • Stephen (stepheny@ust.hk)

4. Course Perspectives Case Overview

5. What is this course about? • Gives an introductory overview of biotechnology in the medical-related areas • Discusses past history, current status and future outlook • Explains basic technologies • Addresses windows of business opportunities • Uses case-study format to highlight developments representative of the industry • Invites speakers to give first-hand stories

6. The Recurring Theme Unmet Health Care Needs of the Society Innovations from Modern Biotechnology Commercial Opportunities

7. An Engineering Approach • Engineer is derived from the Latin word “ingenium”, meaning “invention” • Engineering is the art of directing the great sources of power in nature for the use and the convenience of people -Science and Technology Encyclopedia, McGraw Hill Education .

8. GREAT Class Atmosphere • Grasp • Respect • Exchange • Ask • Teamwork

9. At the completion of this course, you will be able to…. • describe the major areas covered by medical biotechnology • explain the basic technical concepts, scientific and engineering principles • describe the opportunities and challenges faced by the industry • analyze the potential and impact of modern biotechnology on human health and economy • identify the key components contributing to biotechnology of commercial interest • research topics in biotechnology and its current development

10. Course materials • Course pack (Highly recommended!) • Pick up from TA at the end of this class, pay in next class • Purchase copy from Yuki (room 6113. Email first) • Course web site http://teaching.ust.hk/~ceng109/index.htm • Reserved for 2-hr loan in library • “Introduction to Biotechnology” by Thieman • “Biotechnology: Demystifying the Concepts” by Bourgaize, Jewell and Buiser • CENG 109 course packs • Library course guide (Upcoming)

11. Assessment scheme • Class participation 20% • Classroom involvement via PRS and group discussion • Pop-quizzes (based on readings and lecture materials) • Report malfunction of PRS in the same class • Homework assignments 20% • Graded based on relevance, completeness, organization and presentation • ++, +, or  • No late submission • Mid-term 25% • Multiple-choice and short-question format • Class project 35% There is absolutely ZERO tolerance for academic dishonesty

12. Grouping Exercise 5 students per group At least two card colors Introduce yourself!

13. Class project • Team formation: 5 students, two schools, one team leader • Timeline: • A step-by-step guide to help you finish the project • Submit biweekly assignment (one per team) • First assignment due 18/09: team composition and team name • Final report and a final presentation

14. How do you define biotechnology? “Integrated use of biochemistry, microbiology and engineering sciences in order to achieve technological (industrial) application of the capabilities of microorganisms, cultured tissue cells and parts thereof” -Definition of biotechnology by European Federation of Biotechnology

15. Storage and flow of biological information share common traits in living things www.hearingvoices.com http://aquat1.ifas.ufl.edu/guide/bacecoli.jpg forums.mooseyscountrygarden.com www.wallpaperbase.com

16. All cells use DNA for information storage Structure of a basic unit of DNA (DeoxyriboNucleic Acid) www.vcbio.science.ru.nl http://www.biologie.uni-hamburg.de

17. The Language of a Gene

18. DNA as the replication template library.advanced.org Animalgenome.org

19. DNA is a powerful “hard disk” of biological information • Structure allows any sequence of bases From human genome project: human contains 3146.7 million bases and ~30,000 genes • The duplex enables an accurate “backup”; the complementary strand provides a template for replication • The DNA helix is stable, even in the harsh environment of the inside of the cell • The information stored inside DNA is “readable”

20. Central dogma governs the flow of biological information “Biotechnology:Demystifying the Concepts” Bourgaize, Jewell, Buiser

21. The Universal Codes

22. Demonstration of Personal Response System

23. Which picture gives an illustration of biotechnology? 3 1 2 Photo: HK Dairy Farm 5 6 www.karlstrauss.com 4 Photo: FDA

24. Structure of this course • Focus on modern medical biotechnology development. • Part I: Roots of Modern Biotechnology • Classic biotechnology recombinant products and biotechnology giants in US • Part II: Supporting technologies • Protein and drug delivery • Microarrays (e.g. DNA chips) • Part III: Future paradigms • New technologies • Biotechnology start-ups • University roles • Development in Hong Kong and China