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Trans-dominant inhibition of PARP-1 inhibits DNA repair and cell survival

Trans-dominant inhibition of PARP-1 inhibits DNA repair and cell survival following MNNG treatment. Microneedle microinjection technique. Purified repair proteins, antibodies DNA damaged substrates. MNNG. Injection (cyt. / nuclei). Hela. DNA damaging treatment Single cell repair assay:

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Trans-dominant inhibition of PARP-1 inhibits DNA repair and cell survival

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  1. Trans-dominant inhibition of PARP-1 inhibits DNA repair and cell survival following MNNG treatment Microneedle microinjection technique Purified repair proteins, antibodies DNA damaged substrates MNNG Injection (cyt. / nuclei) Hela DNA damaging treatment Single cell repair assay: [3H ] TdR incorporation UV C5RO Molinete et al. (1993) EMBO J. 5, 2109 Schreiber et al. (1995) PNAS, 92 4753-4757

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