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Resting Membrane Potential

Resting Membrane Potential. Whitney Theis March 31, 2006. Charge of a Cell. Normally a cell is more negative on the inside On average -70mV The negative charge forms a thin layer along the inside of the membrane. Major Players in Resting Potential. Na + , K + , and Cl -

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Resting Membrane Potential

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  1. Resting Membrane Potential Whitney Theis March 31, 2006

  2. Charge of a Cell • Normally a cell is more negative on the inside • On average -70mV • The negative charge forms a thin layer along the inside of the membrane

  3. Major Players in Resting Potential • Na+, K+, and Cl- • The resting potential due to the efflux of K+ out of the cell • Leaky channels • Relative concentrations

  4. Development of Resting Potential • Cell thrown out of resting potential when impulse occurs across membrane • When this happens the ATPase pump offsets the action • There are K and Na channels that are always open • K flows out faster than Na

  5. ATPase Pump • Allows two potassium ions in and three sodium ions out • This pump offsets the slow leak of Na+ into the cell • The leaky potassium channels are not offset by the pump • Thus membrane potential due to eflux of potassium

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