Group 1: Cell and Development ‘’Team Verizon’’

1. Group 1: Cell and Development‘’Team Verizon’’

2. Our Network: • Deborah Clark, Oregon State University • Claire Cronmiller, University of Virginia • Bob Mason, Oregon State University • Sarah O’Leary, Illinois Math and Science Academy • Indira Rajagopal, Oregon State University • Sue Styer, Illinois Math and Science Academy • Mike Wormington, University of Virginia • Facilitator: Tina Garza, University of Texas

3. Learning Goal • Can you hear me now? Using signal transduction communication to direct or change cellular physiology.

4. Learning Objectives • 1. Describe the diversity/categories of signals and signaling receptors • 2. Describe the sequence of events (including mechanisms and amplification) from receptor to cellular response • 3. Recognize the diversity of types of cell responses to signals (outcomes) • 4. Hypothesize or diagnose how the same outcome can come from differing pathways or potential signal transduction pathway defects etc.

5. Cell signaling is important for… Neural transmission Fight or Flight Differentiation Tissue Patterning

6. When cell signaling goes wrong… Tissue Patterning Aberration Growth Regulation

7. What’s the Challenge?

8. Activity 1 Goal • Recognize the challenge of transmitting signals to cells.

9. Learning Activity • Tell students that a message (on a piece of paper) has to get from an individual in the front of the class (outside the cell) to the entire back of the class (inside the cell/nucleus) • Provide students with the rules as to what a cell can and cannot do to communicate • Have them brainstorm ideas, keeping in mind the constraints of the cell, on how to relay the message • Have each group report back with their ideas and discuss • Do the message relay demo • Discuss the difficulties of getting the signal transmitted in the activity and relate to what’s happening in the cell

10. Mini Lecture inserted here: • Addressing Learning Goal 1: describe the diversity/categories of signals and signaling pathways • Examples of different signals, types of receptors • Molecular structures and figures shown • Conservation of signaling molecules across species

11. Activity 2 : Goal • Formative assessment of mini lecture • Level 1 or 2 Blooms

12. Activity 2: Think-Pair-Share Following 2 slides

13. Diverse Signaling Molecules Bind to Cell Surface Receptors Epinephrine Acetylcholine Epidermal Growth Factor

14. Epinephrine Acetylcholine EGF Can You Predict Which Signal Binds to Which Receptor Merely By Examining Its Structure?

15. Activity 3: Goal • Recognize the implications of the specificity of cell signaling networks.

16. If the signaling network disrupted in the tumor example were similarly disrupted in the steer, the steer would: A. Eventually develop an eye tumor B. Lack a flight response C. Both A & B Activity 3: Example of Clicker Question

17. Ligand/Receptor -- Cellular Response?