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Nematode, Insect, Human Triangle - with a Difference

Nematode, Insect, Human Triangle - with a Difference. By John M. Webster, Jason Li* & Genhui Chen*. Department of Biological Sciences Simon Fraser University and * Welichem Biotech Inc. WBI-8801. Effect of WBI-8801 on TNF- a Production in Animals. WBI-8801 concentration ( µM).

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Nematode, Insect, Human Triangle - with a Difference

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  1. Nematode, Insect, Human Triangle- with a Difference By John M. Webster, Jason Li* & Genhui Chen* Department of Biological Sciences Simon Fraser University and * Welichem Biotech Inc.

  2. WBI-8801 Effect of WBI-8801 on TNF-a Production in Animals

  3. WBI-8801 concentration (µM) Effect of WBI-8801 on IFN-γ production by human T-cells

  4. Key properties of WBI-8801 • Decreases T-cell activation • Decreases T-cell traffiking • Inhibits selective cytokines • Zero to low toxicity • Anti-inflammatory • Inhibition of keratinocyte proliferation • Safe and fast-acting Potential anti-psoriasis therapeutic

  5. Ag T Cell APC Pathogenesis of Psoriasis Proliferating skin cells TCR MHC

  6. Safety Efficacy Most Important issues Psoriasis therapies

  7. Acknowledgements We appreciate the assistance of the Insectary and the Animal Care Facility at Simon Fraser University, and financial support from NSERC and NRC-IRAP for different components of this research

  8. Welichem Smart Drug Targets Welichem Focus • Two Strategies for Success: • Adhesion molecules (blue) • Cytokines (red) • Welichem targets certain cytokines

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