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The ON going T elmisartan A lone and in

ONTARGET. 替米沙坦单独及联合雷米普利 疗效的全球性试验. The ON going T elmisartan A lone and in combination with R amipril G lobal E ndpoint T rial. Salim Yusuf, Koon K. Teo, Janice Pogue, Leanne Dyal, and Ingrid Copland, Population Health Research Institute and Investigators.

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The ON going T elmisartan A lone and in

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  1. ONTARGET 替米沙坦单独及联合雷米普利 疗效的全球性试验 The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial Salim Yusuf, Koon K. Teo, Janice Pogue, Leanne Dyal, and Ingrid Copland, Population Health Research Institute and Investigators Yusuf, et al. N ENGL J MED.358;15:1547-1559

  2. ONTARGET 三组药物血压变化 (mmHg) Yusuf, et al. N ENGL J MED.358;15:1547-1559

  3. 替米沙坦 雷米普利 累计危险发生率 随访（年） 患者例数 替米沙坦 6478 8542 7954 7384 6909 6254 雷米普利 8576 7796 7165 6681 ONTARGET 两组患者停药率相似 24.5% 23.0% Yusuf, et al. N ENGL J MED.358;15:1547-1559

  4. ONTARGET 患者停药原因 Yusuf, et al. N ENGL J MED.358;15:1547-1559

  5. 替米沙坦 累计发生率 雷米普利 随访（年） 患者例数 8176 7778 7420 7051 8542 替米沙坦 8214 7832 7473 7095 8576 雷米普利 ONTARGET 两组主要终点事件发生率无差别 16.7% 16.5% Yusuf, et al. N ENGL J MED.358;15:1547-1559

  6. ONTARGET 两组主要终点事件发生率无差别 Yusuf, et al. N ENGL J MED.358;15:1547-1559

  7. ONTARGET 联合治疗未降低主要终点事件发生率 16.5% 16.3% 累计危险发生率 雷米普利 替米沙坦+雷米普利 随访（年） 患者例数 8576 8214 7832 7473 7095 雷米普利 8502 8134 7740 7377 7023 替米沙坦+ 雷米普利 Yusuf, et al. N ENGL J MED.358;15:1547-1559

  8. ONTARGET 联合用药增加患者不良反应 Yusuf, et al. N ENGL J MED.358;15:1547-1559

  9. 小 结 • 替米沙坦与雷米普利具有相同的降压效果，两组终点事件发生率相似 • 替米沙坦与雷米普利联合使用未减少主要终点事件的发生，同时不良反应明显增多

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