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Ｉｎｔｅｇｒａｔｉｎｇ 　Ｃｅｌｌｓ　 into Tissues

Ｉｎｔｅｇｒａｔｉｎｇ 　Ｃｅｌｌｓ　 into Tissues. Sho Momota. CAM(Cell-adhesion molecules) ECM(Extra cellular matrix). ECM . Proteoglycans Collagen fibers Multiadhesive matrix proteins. CAM. Cadherins Ig (immunoglobulin) super family Selectins Mucins integrins. Ca. N-teminus.

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Ｉｎｔｅｇｒａｔｉｎｇ 　Ｃｅｌｌｓ　 into Tissues

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  1. Ｉｎｔｅｇｒａｔｉｎｇ　Ｃｅｌｌｓ　into Tissues Sho Momota

  2. CAM(Cell-adhesion molecules) • ECM(Extra cellular matrix)

  3. ECM • Proteoglycans • Collagen fibers • Multiadhesive matrix proteins

  4. CAM • Cadherins • Ig (immunoglobulin) super family • Selectins • Mucins • integrins

  5. Ca N-teminus Extra cellular region • Cadherins cell membrane 50-60% of the sequence is identical among different cadherins. C-teminus Cytoplasm

  6. Types of cadherin • More than 40 different cadherins are known • E-cadherin : Preimplantation embryos, non-neural epethelial tissue • P-cadherin : Trophblast • N-cadherin : nervous system, lens, cardiac and skeletal muscle

  7. Character of cadherin • Homophilic (like bind like) E-cadherins bind to E-cadherins P-cadherins bind to P-cadherins E-cadherins usually not bind to P-cadherins

  8. N-CAMs • Group of Ca-independent cell-adhesion proteins • Ig super family of CAMs • Primarily Homophilic interaction • Encoded by a single gene.

  9. Selectin Blood Sialyl Lewis-x antigen Endothelial cell • Extravasation of leukocytes require the successive formation and breakage of cell-cell contacts between leukocytes in the blood and endothelial cells lining the vessels Sugar binding lectin domain P-selectin

  10. Integrin • Heterodimers of  and  subunits • Exhibit relatively low affinities for the ligands

  11. IIb3 integrin platelet Accelerates a formation of clot Collagen or thrombin Conformational change of IIb3 integrin Fibrinogen platelet Activated platelet

  12. Ｄｅａｄｈｅｓｉｏｎ factors • Promote cell migration and can remodel the cell surface Disintegrins ECM RGD sequence

  13. De-adhesion factors CELL CAM ECM Disintegrins

  14. Question?

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