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The Effects of 11-Cis Vaccenyl Acetate on Drosophila melanogaster

The Effects of 11-Cis Vaccenyl Acetate on Drosophila melanogaster. By Jonathan Tam. Insect-Related Diseases. Fleas, Lice, Mosquitoes and Ticks – most responsible for infectious diseases in the United States Plague, transmitted through fleas.

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The Effects of 11-Cis Vaccenyl Acetate on Drosophila melanogaster

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  1. The Effects of 11-Cis Vaccenyl Acetate on Drosophila melanogaster By Jonathan Tam

  2. Insect-Related Diseases • Fleas, Lice, Mosquitoes and Ticks – most responsible for infectious diseases in the United States • Plague, transmitted through fleas http://www.cdc.gov/ncidod/dvbid/plague/world98.htm

  3. Insect-Related Diseases – Malaria • Malaria • Transmitted by Mosquitoes • 5th Cause of the Most Deaths in the World • 1.3 Million Killed in 2002 http://upload.wikimedia.org/wikipedia/commons/c/cb/Malaria_geographic_distribution_2003.png

  4. Pheromones • Any chemical messengers that affect behavior or development of other individuals of the same species http://upload.wikimedia.org/wikipedia/en/7/70/Nasinov_9024.JPG http://upload.wikimedia.org/wikipedia/commons/8/8a/Bug_aggregation.jpg

  5. Main Types of Insect Pheromones • Alarm Pheromones • Trail Pheromones • Queen Mandibular Pheromones – (specifically in honey bees) • Sex Pheromones http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Pheromones.html#Queen_mandibular_pheromone

  6. Pheromones in D. melanogaster • 11 – Cis Vaccenyl Acetate • Only Known Pheromone in Drosophila • Secreted from the Males through Ejaculation • Induce Aggregation Behavior in Drosophila • Known to have an Inducing Affect on Both Males and Females http://www.caymanchem.com/app/template/Product.vm/catalog/10010101/a/z%3Bjsessionid=4E81A18AAEBDA761F5F0F24C8343988D

  7. Pheromone Baiting • Agricultural Technique to Lure Insects Away from Livestock and Growing Plants • Began With Moths (Indianmeal Moth) • Discovery of 11 – cisvaccenyl acetate effect on Drosophila http://www.meojbiz.com/home/appstorage/product/0000000055/Pheromone%20trap.jpg

  8. Sex Pheromones For Baiting • F.C. Su and M.Y. Lin • Types of Traps • Delta Traps, Winged Trap or a Funnel Trap • Usage of Sex Pheromones http://www.avrdc.org/pdf/efsbtrap.pdf

  9. http://vosshall.rockefeller.edu/reprints/VosshallStensmyrNeuron05.pdfhttp://vosshall.rockefeller.edu/reprints/VosshallStensmyrNeuron05.pdf Mutation and Reception

  10. Literature Review 1 • Pingxi Xu, 2005 • Reinitiate Effect of 11 – Cis Vaccenyl Acetate on Drosophila by adding Protein to Food Cultures • Insensitivity to 11 – Cis Vaccenyl Acetate • Inactivity of trichoid neurons in Drosophila

  11. Literature Review 2 • Ha and Smith, 2006 • Locate the Sensilla in the Antennae missing for 11 – Cis Vaccenyl Acetate detection • Receptors – T1Sensilla, T1 neurons responsible for sensitivity

  12. Literature Review 3 • Kruse, Zhao, Smith and Jones, 2003 • Found Alcohol attraction in Lush Flies due to Protein Binding to Alcohol • Hydroxyl group of alcohol forms hydrogen bonds to the amino acids of the Lush Protein

  13. Bibliography Ha, Tal Soo and Smith, Dean P. “A Pheromone Receptor Mediates 11-cis-Vaccenyl acetate-induced Responses in Drosophila. 23 August 2006. Department of Pharmacology and Center for Basic Neurosciences, University of Texas Southwestern Medical Center. 3 May 2009 "Pheromones - Types." Medindia - Medical/Health Website. 17 May 2009. "Pheromones." RCN New York City. 17 May 2009. ScienceDaily. "Unique Pheromone Detection System Uncovered." Science Daily. 27 June 2008. UT Southwestern Medical Center. 3 May 2009. ScienceDaily. "One Missing Gene Leads to Fruitless Mating Rituals." Science Daily. 25 July 2008. Duke University Center. 3 May 2009. Seybold, Steven J and Donaldson, Susan. “Pheromones in Insect Pest Management.” University of Nevada Cooperative Extension. 1995. University of Nevada 3 May 2009 Xu, Pingxi. "A Drosophila OBP Required for Pheromone Signaling." Science. 4 November 2005.Eppendorf Essays on Science and Society. 3 May 2009 Voght, RG. “Molecular Basis of Pheromone Detection in Insects.” Comprehensive Insect Physiology, Biology, Pharmacology and Molecular Biology, Volume 3, Endocrinology. 2005. Elsevier. 3 May 2009 Wagner, C Michael, Jones, Michael L, Twohey, Michael B and Sorensen, Peter W. “A field test verifies that pheromones can be useful for sea lamprey control in the Great Lakes.” Rapid Communications. 14 January 2006. Department of Fisheries and Wildlife. 3 May 2009 "Wake Up and Smell The Pheromones." The Rockefeller University - Laboratory of Neurogenetics and Behavior. 20 Jan. 2005. 17 May 2009.

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