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Sliver penetrating the skin 

Sliver = Non-specific Immunity. Inflammatory response = second line of defense. Neutrophils leave the capillary to try to attack. They release histamine. Histamine triggers the inflammatory response. Blood clotting.

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Sliver penetrating the skin 

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  1. Sliver = Non-specific Immunity Inflammatory response = second line of defense • Neutrophils leave the capillary to try to attack. They release histamine. Histamine triggers the inflammatory response. Blood clotting • Blood clots to try to stop infection from spreading. Skin becomes swollen, red and painful. • If neutrophils become damaged, they release a chemical signal (chemotaxis) that warns other neutrophils Sliver penetrating the skin  neutrophil

  2. This is an example of the blood vessel dilating (vasodilatation) so more blood can go to the source and fight off the foreign object – or infection

  3. In a normal situation, the inflammatory response would kill the bacteria from the sliver and then your body would reject it, and push it out. -or you pull it out yourself…ouch! BUT… If the infection keeps progressing and gets past the neutrophils and clotting, it turns into a more serious infection in the blood stream.

  4. Pryogens: Molecule that sets the body’s thermostat at a higher temperature. Pryogens then set the body at a higher temperature to help kill off the bacteria or infection. Monocytes are then signaled to “eat” the infection and kill it. They seep through the vessel wall and develop into a macrophage (“big eater”) to kill the infection more efficiently.

  5. Septic Shock (septic = pertaining to infection) • Septic Shock can happen with any type of bacteria (lets say the bacteria that was on the sliver). • It happens in people mostly who are young or old…or already sick. • Inflammation starts to happen everywhere as the body tries to fight off the infection. • Organs and cardiac function can get damaged from all the inflammation.

  6. Septic Shock • Soon the body’s temperature rises to make the WBC grow faster..but that also makes the bacteria grow faster. • Eventually, the body is trying so hard to fight off the infection, that more fluid seeping out of the vessels then it is going into the vessels…everywhere in the boby. • The brain doesn't get enough oxygen and you pass out. • With out help, you could fall into a coma. • And then death.

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