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Block Day- 3/7/12

Block Day- 3/7/12. Homework: -Design your own protein pathway Project - due Friday -Protein Pathways/Protein Structure QUIZ - FRI - DID YOU MISS MONDAY’S CHECKUP ?-. Serotonin Pathway. Homework Check. Circle your answer: How does a MAO inhibitor treat depression?

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Block Day- 3/7/12

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  1. Block Day- 3/7/12 Homework: -Design your own protein pathway Project- due Friday -Protein Pathways/Protein Structure QUIZ- FRI - DID YOU MISS MONDAY’S CHECKUP?-

  2. Serotonin Pathway

  3. Homework Check Circle your answer: • How does a MAO inhibitor treat depression? It decreases or increases the amount of serotonin. Circle your answer: • If the AAAD enzyme doesn’t work, will there be higher or lower amounts of serotonin?

  4. Serotonin Pathway

  5. Serotonin Homework Answers: • Less serotonin • Higher serotonin • Lower serotonin • Blocks the enzyme MAO from working which keeps serotonin available and decreases depression.

  6. Make an entry: Entry 19: Fruit Fly Eye Color- 3/7/12 Tape in picture and take notes

  7. Drosophila Eye Color Pigment Network OMMOCHROME PIGMENTS PTERIDINE PIGMENTS 2-amino-4- hydroxypterdine (BLUE) Molecule A (colorless) 1 Molecule B (colorless) 3 xanthopterin (GREEN-BLUE) 2 9 4 tetrahydroiopterin ommochrome pigment (BROWN) isoxanthopterin (VIOLET-BLUE) 7 6 5 biopterin (BLUE) drosopterin (ORANGE) sepiapterin (YELLOW) 8 10 isosepiapterin (YELLOW) In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network) Color of fly is result of mixture of all pigments in network

  8. White Scarlet Wild Type Brown

  9. Red= need 1-8, 10- missing #9 Wild Type (red-brown)= need all 10 Brown= 9, 10 needed, must be missing #1 White= missing #10- no way color transported OMMOCHROME PIGMENTS PTERIDINE PIGMENTS 2-amino-4- hydroxypterdine (BLUE) Molecule A (colorless) 1 Molecule B (colorless) 3 xanthopterin (GREEN-BLUE) 2 9 4 tetrahydroiopterin ommochrome pigment (BROWN) isoxanthopterin (VIOLET-BLUE) 7 6 5 biopterin (BLUE) drosopterin (ORANGE) sepiapterin (YELLOW) 8 10 isosepiapterin (YELLOW) In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network) Color of fly is result of mixture of all pigments in network

  10. Metabolic Network Project

  11. Make an entry- Entry 20: Protein Quiz Review- 3/7/12

  12. Glucose Lactose Lactase Galactose Key: Metabolites Enzyme reactions

  13. Labrador (dog) pigmentation Yellow pigment tyrosinase Tyrosine Dopaquinone TRP-2 Brown pigment TRP-1 Boxes = metabolites Arrows = enzymes that change the metabolites Black pigment

  14. Adrenaline Noradrenaline 6 Dopaquinone Melanin 1 Dopamine 2 4 Thyroxine Dopa Maleyl- acetoacetate 5 3 Hydroxy- phenylpyruvate Tyrosine Phenylalanine Tyramine Homogentisic acid Prephenate Phenylpyruvate

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