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“TISSUE PLASMINOGEN ACTIVATOR” (t-PA) PLASMINOGEEN PLASMINE

“TISSUE PLASMINOGEN ACTIVATOR” (t-PA) PLASMINOGEEN PLASMINE (inactief) (actief) FIBRINE FRAGMENTEN (vast) (vloeibaar). IBL-1. IBL-2. t-PA MILESTONES 1979 : Ontdekking van “Bowes” melanoma cellijn als bron van t-PA

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“TISSUE PLASMINOGEN ACTIVATOR” (t-PA) PLASMINOGEEN PLASMINE

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  1. “TISSUE PLASMINOGEN ACTIVATOR” (t-PA) PLASMINOGEEN PLASMINE (inactief) (actief) FIBRINE FRAGMENTEN (vast) (vloeibaar) IBL-1

  2. IBL-2

  3. t-PA MILESTONES 1979: Ontdekking van “Bowes” melanoma cellijn als bron van t-PA - Zuivering, biochemische en therapeutische karakterisering in Leuven - Samenwerking met Genentech gestart eind 1980 1982: Klonering van t-PA cDNA en productie van recombinant t-PA (rt-PA) - Karakterisering van rt-PA in Leuven en San Francisco - Klinische evaluatie gestart in 1984 1987: Registratie van rt-PA in USA - Van 1987 tot 2004 > 5 miljoen patienten met AMI behandeld > 120 miljoen € naar LRD, vzw (en opvolgers) IBL-3

  4. t-PA ROYALTIES 100 -17% overhead 83 -21.25% Belgische belastingen 66 33 33 LRD, vzw D. Collen 16.5 16.5 + 16.5 16.5 LRD, vzw D. Collen Research Foundation - mede-uitvinders - Thromb-X (NV) - Cotpa (charity) IBL-4

  5. Molecular Cardiovascular Medicine Group Katholieke Universiteit Leuven, Belgium Campus Gasthuisberg Director D. Collen, M.D., Ph.D. 9th floor KU LEUVEN Thromb-X, NV Center for Molecular and Vascular Biology Adjunct Directors H.R. Lijnen, Ph.D. Center for Transgene Technology and Gene Therapy Adjunct Director P. Carmeliet, M.D., Ph.D. Thromb-X, N.V. Managing Director J.M. Stassen, Ph.D. IBL-5

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