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Molecules involved in T cell activation

Ce ll-mediated im mune response Activation of T lymphocytes by intracellular microorganisms Phases of T cell response Biochemical pathways of T cell activation Functional responses of T lymphocytes to antigens and costimulation. Molecules involved in T cell activation. TCR. TCR complex.

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Molecules involved in T cell activation

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  1. Cell-mediatedimmune responseActivation of T lymphocytes by intracellular microorganismsPhases of T cell responseBiochemical pathways of T cell activationFunctional responses of T lymphocytes to antigens and costimulation

  2. Molecules involved in T cell activation TCR TCR complex Costimulators

  3. Requirement for two signals in T cell activation

  4. Molecules involved in T cell activation Coreceptor Adhesion molecule

  5. Molecules involved in T cell activation Accessory molecules

  6. Molecules involved in T cell activation Immunological synapse

  7. Biochemical pathways ofT cell activation

  8. Clustering of two or more TCRs

  9. Functional responses of T lymphocytes to antigens and costimulation

  10. Clonal expansion of T-limphocytes

  11. Th1 Naïve CD4+T Naivna CD4+T Treg Th2 Diferentiation od CD4+ T-limphocytes IFN-g IL-12+IL-18 IL-4 TGF-b+IL-6 Th17 IL-23… TGF-b

  12. IL-12+IL-18 T-bet Th1 IL-4 GATA-3 Naivna CD4+T Treg TGF-b+IL-6 IL-23… RORgt TGF-b Th2 FoxP3 Diferentiation od CD4+ T-limphocytes IFN-g Naïve CD4+T Th17 Th17

  13. Diferentiation of naiveCD4+ T-cells

  14. Diferentiation od CD8+ T-limphocytes

  15. 1. Recognition of antigen by T cells is mediated by a. IL-2 b. stabilize binding of T-cells to APC 2. Signal transduction in T cells is mediated by c. a and b chains of TCR 3. Accesory molecules involved in T cell activation are d. two signals 4. Costimulatory signals for T cell activation are provided by e. NFAT, NF-kB and AP1 5. T cell growth factor is f. CD28 and B7 molecules If APC does not express costimulatory molecules 6. g. CD3, CD4, CD8, CD28 and adhesion molecules 7. Adhesion molecules 8. Activation of naive T-cells requires h. IL-12 9. Cytokine that is crucial for TH1 differentiation is i. T cell is not activated 10. Main transcription factors in T cell activation are j. CD3 complex and z chains c j g f a i b d h e 1.____ 2.____ 3.____ 4.____ 5.____ 6.____ 7.____ 8.____ 9.____ 10.____

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