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NC A&T State University Made History

NC A&T State University Made History. NOW…..THE REST OF MY STORY. KNOWN FACTS……..MUST BECOME REALITY :. Partnership (small or big) must transcends all boundaries True Partnership takes place at the intellectual level (Performance level and Wavelength) – PASSION DRIVES THEM

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NC A&T State University Made History

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  1. NC A&T State University Made History

  2. NOW…..THE REST OF MY STORY KNOWN FACTS……..MUST BECOME REALITY: Partnership (small or big) must transcends all boundaries True Partnership takes place at the intellectual level (Performance level and Wavelength) – PASSION DRIVES THEM Sacrifices at all levels…….Leaders in the trust sense Nothing comes EASY.… it has to Be Earned Intangibles and Luck will help - for those in the High level performance and partnership zone

  3. Center for Advanced Materials and Smart Structures (CAMSS) - Foundation for the ERC High Profile Broad Based Materials Activities over 20 years NSF-NSEC(2004 - NSF-NIRT(2005- 10) DoD-CNN (2003 – 2011) Other NSF, AFRL, ONR, NASA-NIA Others NSF-CREST 1997-2008 • Four (4) National Broad-based • Advanced, Nano Centers • Leveraging and Strategic Resources • Sharing • Maximum output for each $ spent • Innovative thinking that cuts across areas RECENT competitive Programs WON: NSF-US/Europe Collaboration, NSF-MRIs, Various NSF-SBIRs,STTR, NSF- NUE (2), DoD-Nanolithography, DoD-DURIP

  4. NCAT Facilities: A Foundation for Partnership and Innovation Ecosystem Pulsed Laser Deposition Facility Fuel Cell Processing Laboratory Coatings Synthesis Laboratory Bio/Polymer Laboratory Composite Processing Laboratory Materials Processing and Sample Preparation Laboratory Microscopy and Surface Analysis Facility Electron Microscopy Laboratory Computation and Visualization Lab Nanoindentation Facility Mechanical Testing /High-Temperature Testing Facility Structural Health Monitoring Research Laboratory X-ray Diffraction Facility Physical Property Measurement Lab Catalysis Facility Electronic Materials Laboratory Magnetron Deposition Facility Direct Write Nano-Fludics Analysis Facility Micro-Raman facility Clean Room with Ink Jet, High Speed Camera and Nanolithography Bioengineering ERC General facility FSEM, AFM, Nano CT Interconnected Labs Facility, Research, knowledge without boundaries

  5. REST OF MY STORY CENTER Ethics lay a strong foundation for its growth and true partnership - it is adaptable to innovative technologies and education Partnership is Ready to Contribute with Customer Focus OTHER ingredient for true partnership: “Quality (track record)” “Strong on deadlines and deliverables” ERC Faculty ACROSS PARTNER INSITUTIONS – T Function

  6. National Science Foundation – Gen 3“THIS GREW OUT OF OUR RELATIONSHIP AND TRACK STRENGTH”Engineering Research Centerfor “Revolutionizing Metallic Biomaterials” Mark Schulz Devdas Pai Bill Wagner Frank Witte Harvey Borovetz Executive Director (Pitt) Global Site Coordinator(MHH) Education & Outreach Director (NCAT) Deputy Director (UC) Deputy Director (Pitt)

  7. National Priority to become the Global Leader Complex fractures of the Tibia and Femur: Need for Resorbable Fixation Plates, Pins and Screws Before After Malformations • will create biodegradable metals with the promise that new kinds of implants can adapt to the human body and eventually dissolve when no longer needed, eliminating multiple surgery and reduce health care costs • “Imagine Implants with their own intelligence that adapt to biological • changes of the patient and are automatically eliminated from the body after healing” Cleft Lip • TRAUMA Medical spending: Close to $250 billion • Total knee replacement surgeries increased by 85% in the recent years. • % mini plate surgeries led to infection 64% of Ti plate fixations need to be removed due to complications, infections, pain • stents are difficult to remove and additional stents must be inserted (elicit an immune response that can lead to the growth of scar tissue and the formation of blood clots) • Value of regenerative implants, Degradable metal anchors, screws, plates, stents and drug eluting stents, staples, sutures, sternal wires, and meshes • PRICELESS

  8. ACL Screw Development Strategic Plan“Partnership both Inside and from Outside” Alloy Design & Development Xu (NCAT) Kumta (Pitt) Shanov(UC) Clinical Trials J&J DepuyMitek Screw Design & Manufacture Woo, McMahon, Tei & Kim(Pitt) Schulz & Yin (UC) Kumta (Pitt) Xu (NCAT) Biomechanics & In-vitro Functionality Woo & Kim (Pitt) Toxicology & Functional Biocompatibility Dong (UC) Barchowsky (Pitt) Industry Surface Treatment Yun & Yarmolenko (NCAT) Vanooij (Ecosil LLC) Shanov (UC) In-Vivo Animal Models Woo & Kim McMahon & Tei (Pitt) Alloy Corrosion & Degradation Yun (NCAT) Dong (UC) Material Characterization Schulz & Yin (UC) Xu (NCAT) Controlled Drug Release Wagner (Pitt) Orthopedic Surgeons Patrick McMahon Marc Philippon, Richard Steadman, James Bradley, Frank Witte Matteo Tei (Resident) Industry J&J Depuy Mitek Alonzo Cook Gary McAlistar Design Objectives (ERC Team)

  9. E & O Partnership Strategic Plan

  10. ACL Fixation Screw Medical System In-vitro ACL reconstruction using bone-patellar tendon-bone (BPTB) graft Graft fixation using interference screws Mg-based screws (Mg & AZ31 alloy ); Titanium screws as control Interference Screw Screws Mg Screw Commercial Titanium Screw NCAT Veterinarian and Animal Surgeon – Getting trained at Pitt Minimal degradation 6 wk post-implant

  11. Bioreactor Development at NCAT with Pitt Partnership Alcian Blue Stain Glycosaminoglycans Ex Vivo Models For Biologic and Mechanical Evaluation Confidential

  12. Strategic Plan for Biosensors Clinical Trials Sensor design Heineman (UC) Kumta (UPitt) Toxicology Pixley (UC) Processing Shanov (UC) Yun (NCAT) Kumta (UPitt) Industry Alloys Xu (NCAT) Kumta (UPitt) In vivo Models Witte (MHH) Dong (UC) Functional Biocompatibility Sfeir, Gilbert, Cui (UPitt) Characterization Schulz (UC) Yun (NCAT)

  13. RESIDUE OF TRUE PARTNERSHIPRMB - Materials Database for Medical Devices - MD2 Key world leaders have accepted our requests to be a part of this materials database collection systemand now with ASM- International

  14. Workshop at the FDA+ Multiple Global Biometallic Materials Conferences http://erc.ncat.edu/biodegradablemetals

  15. NCAT- Bioengineering Program BS, MS – ongoing and Ph.D on its way- History in Making Gatchell, Linsenmeier, CoC,2/07 NCAT FIRST HBCU AMONG THESE 80+ PROGRAMS! Total UG Programs Dr. Borovetz and Pitt- Bioengineering Program – an Integral part of the development activities Accredited

  16. ERC Impact via Effective PartnershipFully - Integrated Management Development of an Innovative, Globally Competitive Research, Education and Diverse Engineering Workforce Academic Programs Educational Outreach Technical Dissemination Economic Development BS, MS and Ph.D in Bioengineering K-14 SBIR/ STTR Conferences Symposia Seminars Frontier/ Transformational Scientific Research Innovate “R” with Partners REU/ LS-AMP/OPT-ED Distance Learning “D” with Local/Partner Companies Innovation Conferences Symposia Spin-off Companies Entrepreneurship Publications Teaching the Teacher/RET

  17. Hitachi Johnson & Johnson CSAB “One Team ....One Dream” Em2 Machine Inc

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