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Antigenic Shift v. Drift in Avian and Mammalian Sino-Influenza Type A Viruses.

Antigenic Shift v. Drift in Avian and Mammalian Sino-Influenza Type A Viruses. By Charles Hauser, St. Edward’s University Mark Maloney, Spelman College Young Kim, Northland College Michael P. Saclolo, St. Edward’s University. Issues. Role of viral hemagglutinin diversity in pathology

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Antigenic Shift v. Drift in Avian and Mammalian Sino-Influenza Type A Viruses.

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  1. Antigenic Shift v. Drift in Avian and Mammalian Sino-Influenza Type A Viruses. By Charles Hauser, St. Edward’s University Mark Maloney, Spelman College Young Kim, Northland College Michael P. Saclolo, St. Edward’s University

  2. Issues • Role of viral hemagglutinin diversity in pathology • Creation of new viral strains • Antigenic shift versus drift

  3. Influenza type A Subtypes designated by Hemagglutinin (H) and Neuraminidase (N) expression

  4. Subtypes • H and N are on surface • H and N are components of flu vaccines • Subtypes A (H1N1) and A (H3N2) are common human viruses

  5. Vaccines must match subtype and specific strain • New flu viruses evade immunity: • Antigenic Shift vs. • Antigenic Drift

  6. Antigenic Shift • New subtypes match different H and N genes • Avian and human viruses mix and match in swine

  7. Antigenic Drift • Small differences in sequence within a subtype define strains • “alleles” or different versions of same H genes

  8. BIRD FLU • “Bird flu” is unusual • Some strains of avian subtypes (H5N1, H9N2, H7N7) can directly infect humans

  9. Module Components • Chinese Avian and Mammalian Influenza Hemagglutinin Sequences • ClustalW Alignment • Dendogram Analysis

  10. H9N2 H3N2 H1N1 H5N1

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