Biology of Bone Repair

1. Biology of Bone Repair J. Scott Broderick, MD Original Author: Timothy McHenry, MD; March 2004 New Author: J. Scott Broderick, MD; Revised November 2005 General references for this talk: Albright JA, Brand RA. (ed.) The Scientific Basis of Orthopaedics. (2nd ed.) Appleton and Lange, 1987. Buckwalter JA, Einhorn TA, Simon SR (ed.) Orthopaedic Basic Science 2nd Ed. AAOS, 1999. Favus MJ (ed.) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 4th Ed. Lippincott Williams and Wilkins, 1999. Hughes SPF and McCarthy IA. (ed.) Sciences Basic to Orthopaedics. WB Saunders Co., 1998. Simon SR. (ed.) Orthopaedic Basic Science. AAOS, 1994. Beaty, JH. (ed.) Orthopaedic Knowledge Update. AAOS, 1999. Additional references specific to each slide are indicated in the notes section of the slides. Photomicrographs as noted are courtesy Gwen Childs, PhD, Professor and Chair Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock, AR who owns copyright and seen on website http://cellbio.utmb.eduGeneral references for this talk: Albright JA, Brand RA. (ed.) The Scientific Basis of Orthopaedics. (2nd ed.) Appleton and Lange, 1987. Buckwalter JA, Einhorn TA, Simon SR (ed.) Orthopaedic Basic Science 2nd Ed. AAOS, 1999. Favus MJ (ed.) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 4th Ed. Lippincott Williams and Wilkins, 1999. Hughes SPF and McCarthy IA. (ed.) Sciences Basic to Orthopaedics. WB Saunders Co., 1998. Simon SR. (ed.) Orthopaedic Basic Science. AAOS, 1994. Beaty, JH. (ed.) Orthopaedic Knowledge Update. AAOS, 1999. Additional references specific to each slide are indicated in the notes section of the slides. Photomicrographs as noted are courtesy Gwen Childs, PhD, Professor and Chair Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock, AR who owns copyright and seen on website http://cellbio.utmb.edu

2. Types of Bone Lamellar Bone Collagen fibers arranged in parallel layers Normal adult bone Woven Bone (non-lamellar) Randomly oriented collagen fibers In adults, seen at sites of fracture healing, tendon or ligament attachment and in pathological conditions

3. Lamellar Bone Cortical bone Comprised of osteons (Haversian systems) Osteons communicate with medullary cavity by Volkmann�s canals