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Cancer cells grow and divide when they should not. Mitosis – an asexual cell division, that occurs in somatic cells “Soma” = body Cell cycle – the “lifecycle” of the cell. The Cell cycle: Interphase. Interphase has three phases: G 1 : cell grows, organelles duplicate
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Cancer cells grow and divide when they should not • Mitosis – an asexual cell division, that occurs in somatic cells • “Soma” = body • Cell cycle – the “lifecycle” of the cell
The Cell cycle: Interphase Interphase has three phases: G1: cell grows, organelles duplicate S: DNA is replicated G2: cell makes proteins needed to complete cell division
DNA replication • Produces exact copies of the cells chromosomes • Nucleotides are added by an enzyme called DNA Polymerase • semiconservative replication - each newly replicated DNA molecule contains a daughter and a parental DNA strand
Following replication, the DNA sequence ACCGTA would be paired with a daughter DNA strand with the sequence: • ACCGTA • TGGCAT • ATGCCA • UGGCAT
DNA replication duplicates chromosomes • Chromosomes are uncondensed before cell division • Duplicated chromosomesare called sister chromatids • They are held together at the centromere
The Cell cycle: Mitosis • Mitosis produces genetically-identical daughter nuclei • Four stages: • Prophase • Metaphase • Anaphase • Telophase • Mitosis is followed by cytokinesis, which splits the two nuclei into two daughter cells