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Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin

Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin. Heparin (long strand) binds to other plasma proteins (colored molecules) and platelets, reducing heparin’s availability to bind to AT.

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Heparin Binds Plasma Proteins; Angiomax ® (bivalirudin) Binds Specifically to Thrombin

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  1. Heparin Binds Plasma Proteins; Angiomax® (bivalirudin) Binds Specifically to Thrombin Heparin (long strand) binds to other plasma proteins (colored molecules) and platelets, reducing heparin’s availability to bind to AT. Heparin-binding proteins are elevated in acute coronary syndromes (ACS). Angiomax (bright blue) binds onlyto thrombin (orange). Angiomax is not neutralized by other plasma proteins or platelets; it remains fully active near thrombus. Weitz JI et al. Thromb Res. 2002;106:V275-V284. Wittkowsky AK. Pharmacother. 2002;22(6 Pt 2):97S-104S. Hirsh J et al. Chest. 2001;119(1 suppl):64S-94S. CM Gibson 2006

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