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The most interesting news about vitamin D for pharmacologists. London 17.09.20111 Author: Dr. Anna Dorothea Höck E-Mail: ad.hoeck@t-online.de. Old. New. Genomic (via gene expression )
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The most interesting news about vitamin D for pharmacologists London 17.09.20111 Author: Dr. Anna Dorothea Höck E-Mail: ad.hoeck@t-online.de
Old New London 18.09.2011
Genomic (via geneexpression) Pike JW, et al. EndocrinolMetabClin North Am 2010;39(2):255-69 Pan YZ, et al. Drug MetabDispos 2009;37(10):2112-7 KomagataS, et al. Mol Pharmcol 2009; 76(4):702-9 • Non-genomic (via cell-signaling) YuC, et al. Int J BiochemCellBiol 2011;43(1):41-6 Shin JS, et al. Zhao G, et al. Steroids 2010;75(8-9):555-9 Dixon KM, et al. J Steroid Mol Biol 2007;103(3-5):451-6 NEW: Non-genomicactionsseemtobenecessaryforgenomicactionsOrdonez-Moran, et al. Cellcycle 2009;8(11):1675-80 London 18.09.2011
Theman TA, et al. Curr Pharm Biotechnol 2009;10(3):289-301 London 18.09.2011
Well known: New: Löffler G, Petrides PE, 8th edition, Springer, Germany London 18.09.2011
The complexity of calcium metabolism Known And imaginable consequences ofcalcium deficiency London 18.09.2011
Löffler G, Petrides PE, 8th edition, Springer, Germany London 18.09.2011
Harrison‘sPrinciplesofMedicine. 17th edition. London 18.09.2011
A possible link betweencalcium deficiency andinflammation Low calciumstores High calcium Stores • Boneresorptionishyperactive (a proinflammatory event). Fleet JC. J Musculoskelet Neuronal Interact 2006:6(4):336-7. • Strong innate immune system and regulated, modulated and mitigated adaptive immune system. Panda DK, et al. PNAS 2001;89:7498-7503.Peterlik M, et al. Eur J Clin Invest 2005;35(5):290-304. London 18.09.2011
Cadherin superfamily London 18.09.2011
Cadherin with Calcium and without London 18.09.2011
Role of calcium in muscle Vortrag in Bergisch-Gladbach 10/2011
Ca/Tropomyosin enables muscle contraction London 18.09.2011
Role of calcium in nerve signaling Vortrag in Bergisch-Gladbach 10/2011
The pleiotropic organ protection of vitamin D Immune system Redoxsystem Effects on mitochondria Effects on heartandkidney Effects on aminoacidsandpolyamines Effects on brain autoradiographicvitamin D targets London 18.09.2011
Old New London 18.09.2011
Effects of vitamin D on immune system enhancesinnate Immune System Regulates AND Modulates adaptive immune system London 18.09.2011
Effects of vitamin D on redox-system Reduces oxidative stress Reducesreductive stress London 18.09.2011
Effects of vitamin D on mitochondria Mitochondriaas A possiblemajor link betweenvitamin D deficiency andenergy deficiency (Fatigue)? London 18.09.2011
Effects of vitamin D on amino acid and polyamine synthesis Most publicationsnowoutdated. A forgottenissue. London 18.09.2011
Vitamin D and muscle function Vitamin D statusandmusclestrengthCorrelatepositively. However: furtherstudiesareneededandthemechanismsofaction must becomeclearer. London 18.09.2011
„Vital cellfunctions: proliferation, differentiation, secretion. Strong autoradiographicbindingfound in: skinepidermis, hairfollicles, sebaceousandsweatglands, myoepthelialcells, certainbrainand spinal cordneurons, specificcells in anterior (esp. thyr0tropes) andposteriorpituitary, thymusreticularcells, adrenalmedullarycells, stomachglandisthmuscells, entero-endocrinecells, pyloricmusclecells, pancreasbetacells, heartatrialmyocytes, specialcells in salivaryglands, all population in femaleand male reproductiveorgans, liversinuslittoralcells, perhaps Ito cells. „Stumpf WE. Europ J Drug MetabPharmacokin 2007, 2008. www:walterstumpf.com VDRs not found in: „musclenucleiandfatcells, not atplasmamembranes, howeverfound in groundsubstanceofmucosa.“However: „such negative findings do not excludepossibleactionsundercertainconditions, whichpointtothemeritsoffurtherstudy.“ London 18.09.2011
Löffler G, Petrides PE. 8th edition, Springer , Germany London 18.09.2011
