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Play PPT now to see the answers on by one (i.e., do not view in PPT edit mode)

Play PPT now to see the answers on by one (i.e., do not view in PPT edit mode). Purine biosynthesis, salvage pathways, and inhibitors. Adenine(A). (diaminopurine, DAP). (8-azaadenine, 8AA). Methotrexate. Folate. (=amethopterin). (~aminopterin). Adenosine. APRT. Adenosine. FH4.

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Play PPT now to see the answers on by one (i.e., do not view in PPT edit mode)

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  1. Play PPT now to see the answers on by one(i.e., do not view in PPT edit mode)

  2. Purine biosynthesis, salvage pathways, and inhibitors Adenine(A) (diaminopurine, DAP) (8-azaadenine, 8AA) Methotrexate Folate (=amethopterin) (~aminopterin) Adenosine APRT Adenosine FH4 kinase Nuc. Acid AMP Glycine Thymidine (T) Adenylosucc. Alanosine PRPP + IMP glutamine HGPRT Azaserine XMP GMP Nuc. Acid Hypoxanthine Glutamine XGPRT HGPRT (H) (Eco gpt) Guanine Xanthine Mycophenolic (6-thioguanine, 6TG) (X) (8-azaguanine, 8AG) Test yourself: Fill in the boxes Grow (+) or not grow(-) Click for the answers col. by col. Growth pattern examples GHT = glycine, hypoxanthine, and thymidine A = adenine H = hypoxanthine G = glycine TG = 6-thioguanine (G analog) DAP = diaminopurine (A analog) MTX = methotrexate (DHFR inhibitor) DHFR = dihydrofolate reductase HPRT = hypoxanthine-guanine phosphoribosyltransferase APRT = adenine phosphoribosyltransferase in italics + + - - - + - + - - - + + - + + + + - + + - - - - + - - - + + -

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